人才队伍

 丁克峰，国家重点研发计划首席科学家，浙江大学医学部教授、主任医师、博士生导师。浙江大学肿瘤学学位点负责人，浙江大学求是特聘医师。浙江大学医学院附属第二医院副院长、浙江大学肿瘤研究所副所长、浙江省医学分子生物学重点实验室主任。主持国家“十三五”重点研发计划一项，国家自然科学基金6项，浙江省重点研发计划1项以及多项省部级课题。现担任中国抗癌协会理事，中国抗癌协会大肠癌专业委员会副主任委员；中国医师协会结直肠肿瘤专委会外科专委会主任委员；浙江省抗癌协会大肠癌专业委员会主任委员，浙江省医学会肿瘤外科分会副主任委员。擅长大肠癌腹腔镜微创治疗和综合诊治，率先在全国提出并开展腹腔镜辅助结直肠癌快速康复综合治疗模式，是创建浙江大学大肠癌多学科诊治中心的主要骨干和负责人之一。

社会兼职

中国抗癌协会理事

中国抗癌协会大肠癌专业委员会副主任委员

浙江省抗癌协会大肠癌专业委员会主任委员

浙江省肿瘤转移专业委员会前任主任委员

浙江省医学会肿瘤外科分会副主任委员

浙江省医学会精准医疗学会副主任委员

浙江省医师协会肛肠外科学会副会

研究与成果

1. 学术研究

 丁克峰教授现担任浙江大学医学部博士生导师及博士后合作导师，同时为国家“十三五”重点研发专项首席科学家。主要研究方向为结直肠癌微创外科治疗与晚期肠癌的综合诊治、肿瘤转移的分子机制与新疗法、基于人工智能的肠癌诊疗新体系、结直肠癌专病队列研究以及结直肠癌早期筛查。

2. 成绩特长

 建设浙江大学医学院附属第二医院大肠癌诊治中心，是创建浙江大学大肠癌多学科诊治中心的主要骨干和负责人之一。规范MDT模式，参与全国大肠癌规范化巡讲，协助制定全国《大肠癌诊治规范》，共同制定中国大肠癌MDT技术推广工程的实施方案和标准，负责的病区已成为“全国消化道肿瘤多学科综合治疗学习中心”，推动浙医二院成为“全国结直肠癌多学科综合治疗先进技术示范推广工程”首批示范医院之一。

  2003年起，探索和带动腹腔镜结直肠微创外科手术，为国内、省内最早开展该项创新性技术的医生之一。在这基础上，2009年开始，率先提出和建立起“大肠癌快速康复综合治疗模式（FTMDT）”，主持国际注册的FTMDT多中心临床随机对照研究。研究成果在全国推广应用，明显改善肠癌手术疗效、促进康复，大幅度降低住院日期，大大节约医疗资源。牵头制定了《基于临床多中心研究的结直肠癌加速康复手术综合治疗模式浙江共识》。

 开展大肠癌精准诊疗规范多中心研究，首次发现大肠癌TNM分期系统中的“反常现象”，即IIb/c期患者预后明显差于IIIa期患者，进而创新性地提出T-plus分期系统弥补此缺陷。此项研究成果受邀在2016年亚太胃肠道肿瘤峰会进行大会报告；基于术前精准影像技术准确评估腹腔血管变异及肿瘤分布位置，有效缩短手术时间，降低手术相关出血风险；注册PSSR和SHIP等国际临床试验，探索直肠癌和结直肠癌腹膜转移患者治疗新规范。

 以国家基金课题为依托，开展结直肠肝转移的相关机制研究。构建小鼠肝转移模型，研究肿瘤微环境对于肿瘤发展的作用以及肝转移病灶与原发病灶的特点比较。以结直肠癌肝转移相关基因着手深入探析结直肠癌肝转移的发生机制及相关治疗。同时对结直肠肝转移的手术治疗策略进行系统分析；开展肿瘤耐药相关分子研究，首先发现和研究了肿瘤耐药及凋亡相关新功能分子hBex1的作用及其相关机制。

 2017年起，依托国家“十三五”重点研发计划“结直肠癌专病队列研究”，建设中国结直肠癌专病队列数据库平台（www.ncrcc.org.cn），计划针对肠癌早期筛查、进展期综合诊治以及晚期个性化治疗纳入5万例以上病例数据，从而为中国结直肠癌精准医疗体系的建设记忆肠癌早诊早治的推广提供重要的数据支撑。

3. 科研项目

近5年共主持国家“十三五”重点研发计划1项，浙江省重点研发计划1项，国家自然科学基金面上项目3项，具体如下，按照时间倒序排列：

1）国家自然基金面上项目，结直肠癌来源外泌体通过调控STAT3/IL-1β信号通路介导的肝脏胆固醇合成代谢促进肝转移，2021-2023；55万，负责人（在研）；

2）国家自然基金面上项目，携带ANGPTL1的外泌体改造结直肠癌肝转移前微环境的研究，2018-2021；53万，负责人（在研）；

3）国家重点研发计划“精准医学研究”重点专项，结直肠癌专病队列研究，2017-2020；1404万，负责人（在研）；

4）浙江省重点研发计划，基于生物标志物特征图谱的结直肠癌精准诊疗新规范，2017-2020；130万，负责人（在研）；

5）国家自然科学基金面上项目，Bex1抑制结肠癌肝转移的功能、机制及转化研究。2015-2018；64万，负责人（在研）；

4. 国际注册的自主临床多中心研究项目（负责人）：

1）Study Comparing Conventional and Fast Track Multi-Discipline Treatment Interventions for Colorectal Cancer. ClinicalTrials.gov Identifier: NCT01080547.

2）Randomized Trial of Promary Surgery Followed Selective Radiochemotherapy for Rectal Cacncer With MRI Negative CRM(PSSR). ClinicalTrials.gov Identifier: NCT02121405

3）Trial Evaluating Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Treating Patients With a High Risk of Developing Colorectal Peritoneal Carcinometestasis. ClinicalTrials.gov Identifier: NCT02179489

4）Study Comparing Pursestring Wound Closure vs Conventional Closure to Reverse Stoma of Colorectal Cancer Patients (PURSE). Clinical Trail gov Identifier：NCT02564224

5）Compare Efficacy and Safety of Raltitrexed-based and 5fu-based Neoadjuvant Chemotherapy for Colorectal Liver Metastasis. Clinical Trail gov Identifier：NCT02453490

6）Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China (CLEAR-C). Clinical Trail gov Identifier：NCT04287335

7）Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type mCRC Patients (ALTER-C-002). Clinical Trail gov Identifier：NCT04080843

8）ePRO for Adjuvant Therapy of Gastric and Colorectal Adenocarcinoma. Clinical Trail gov Identifier：NCT04069455

代表性论文

1. Jicheng Wu, Shen Hu, Lihong Zhang, Jinxia Xin, Chongran Sun, Liquan Wang, Kefeng Ding*, Ben Wang. Tumor circulome in the liquid biopsies for cancer diagnosis and prognosis. Theranostics. 2020 Mar.

2. Jiafeng Wang, Xuefei Zhou, Huifang Wang, Qian Xiao, Kefeng Ding*, Xue Dong, et al. Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. Biomaterials. 2020 Oct .

3. Tang Yang, Huang Zhiheng, Wang Zhanhuai, et al: Increased RAB31 Expression in Cancer-Associated Fibroblasts Promotes Colon Cancer Progression Through HGF-MET Signaling. Frontiers in Oncology. 2020. Sep 23.

4.  Lu W, Fu DL, Kong XX, et al: FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms. Cancer Medicine 2020 Jan 1. doi: 10.1002/cam4.2786

5.  Tan Y, Hu Y, Xiao Q, Tang Y, Chen H, He J, Chen L, Jiang K, Wang Z, Yuan Y, Ding K. Silencing of brain-expressed X-linked 2 (BEX2) promotes colorectal cancer metastasis through the Hedgehog signaling pathway. Int J Biol Sci 2020; 16(2):228-238. doi:10.7150/ijbs.38431.

6.  Li J, Kong XX, Zhou JJ, et al: Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study. BMC Cancer 19:988, 2019

7.  Maxwell Hwang, Da Wang,Wei-Cheng Jiang, et al: An Adaptive Regularization Approach to Colonoscopic Polyp Detection Using a Cascaded Structure of Encoder–Decoders. International Journal of Fuzzy Systems October 2019, Volume 21, Issue 7, pp 2091–2101

8.  Yinuo Tan, Dongliang Fu, Dan Li, Xiangxing Kong, Kai Jiang, Liubo Chen, Ying Yuan and Kefeng Ding. Predictors and Risk Factors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer: A Population-Based Analysis. Frontiers in Oncology. 13 June 2019 | https://doi.org/10.3389/fonc.2019.00497

9.  Chen L, Jiang K, Chen H, et al. Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway. Cancer Manag Res. 2018 Dec 20;11:95-105. doi: 10.2147/CMAR.S169476. eCollection 2019.

10. Wang Z, Ye Y, Hu Y, et al. Extent of enhancement on multiphase contrast-enhanced CT images is a potential prognostic factor of stage I-III colon cancer. Eur Radiol. 2018 Sep 25. doi: 10.1007/s00330-018-5689-3

11. Jiang K, Jiao Y, Liu Y, et al. HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model. J Cell Physiol. 2018 Sep 7. doi: 10.1002/jcp.27140

12. Kong XX, Li J, Cai YB, Tian Y, Chi SQ, Tong DY, Hu YT, Yang Q, Li JS, Graeme P, Ying Y, Ding K*. A Modified TNM Staging System for Non-Metastatic Colorectal Cancer Based on Nomogram Analysis of SEER Database. BMC Cancer. vol. 18, 2018/01/10 edn; 2018: 50

13. Chen H, Xiao Q, Hu Y, Chen L, Jiang K, Tang Y, Tan Y, Hu W, Wang Z, He J, Liu Y, Cai Y, Yang Q, Ding K*.ANGPTL1 attenuates colorectal cancer metastasis by upregulating miR-138. Journal of Experimental & Clinical Cancer Research 2017 Jun 12;36(1):78. 

14. Wang Z, Tan Y, Yu W, Zheng S, Zhang S, Sun L, Ding K*. Small role with big impact: miRNAs as communicators in the cross-talk between cancer-associated fibroblasts and cancer cells. International Journal of Biological Sciences.13(3):339-348, 2017.

15. Hu Y, Xiao Q, Chen H, He J, Tan Y, Liu Y, Wang Z, Yang Q, Shen X, Huang Y, Yuan Y, Ding K*. BEX2 promotes tumor proliferation in colorectal cancer. International Journal of Biological Sciences. 13(3):286-294, 2017. 

16. Chen H, Shen Z, Hu Y, Xiao Q, Bei D, Shen X, Ding K*. Association between MutL homolog 1 polymorphisms and the risk of colorectal cancer: a meta-analysis. Journal of Cancer Research and Clinical Oncology. 141(12):2147-2158, Dec 2015.

17. Xiao Q, Hu Y, Liu Y, Wang Z, Geng H, Hu L, Xu D, Wang K, Zheng L*, Zheng S*, Ding K*. BEX1 Promotes Imatinib-Induced Apoptosis by Binding to and Antagonizing BCL-2. Plos One. 9(3): e91782, Mar 2014.

18. Li J, Liu Y, Wang J, Gao Y, Hu Y, He J, Yu X, Hu H, Yuan Y, Zhang S, Ding K*. Oxaliplatin-Based Adjuvant Chemotherapy without Radiotherapy Can Improve the Survival of Locally-Advanced Rectal Cancer. Plos One. 9(9): e107872, Sep 2014. 

19.  Li J, Guo B, Sun L, Wang J, Fu X, Zhang S, Poston G, Ding K*.TNM staging of colorectal cancer should be reconsidered by T stage weighting. World Journal of Gastroenterology. 20(17):5104-5112, May 2014. 

20. Li J, Yi C, Hu Y, Li J, Yuan Y, Zhang S, Zheng S, Ding K*. TNM Staging of Colorectal Cancer Should be Reconsidered According to Weighting of the T Stage Verification Based on a 25-Year Follow-Up. Medicine. 95(6): e2711, Feb 2016.

21. Chen H, Cai Y, Liu Y, He J, Hu Y, Xiao Q, Hu W, Ding K* Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis. Medicine 2016 Feb;95(7).

22. Liu Y, Xu J, Jiao Y, Hu Y, Yi C, Li Q, Tong Z, Wang X, Hu L, Xiao Q, Li J, Ding K*. Neuroendocrine differentiation is a prognostic factor for stage II poorly differentiated colorectal cancer. Biomed Res Int. 2014;2014:789575. doi: 10.1155/2014/789575. Epub 2014 Jun 29. 

23.Zhan X, Sun X, Hong Y, Wang Y, Ding K*.Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. Biomed Res Int . 2017;2017:3809464. doi: 10.1155/2017/3809464. Epub 2017 Jun 8. 

24. Xu D, Li J, Song Y, Zhou J, Sun F, Wang J, Duan Y, Hu Y, Liu Y, Wang X, Sun L, Wu L, Ding K*.Laparoscopic surgery contributes more to nutritional and immunologic recovery than fast-track care in colorectal cancer. World J Surg Oncol. 2015 Feb 4;13:18. doi: 10.1186/s12957-015-0445-5.

25. Liu Y, He J, Xu J, Li J, Jiao Y, Bei D, Hu Y, Chen H, Xiao Q, Ding K*. Neuroendocrine differentiation is predictive of poor survival in patients with stage II colorectal cancer. Oncol Lett.  2017 Apr;13(4):2230-2236. doi: 10.3892/ol.2017.5681. Epub 2017 Feb 7. 

26.Chen H, Hu Y, Xiang W, Cai Y, Wang Z, Xiao Q, Liu Y, Li Q, Ding K*. Prognostic significance of matrix metalloproteinase 7 immunohistochemical expression in colorectal cancer: a meta-analysis. International Journal of Clinical and Experimental Medicine 2015; 8: 3281-3290.

27. Yi C, Huang Y, Yu X, Li X, Zheng S, Ding K*, Xu J*. Clinicopathologic distribution of KRAS and BRAF mutations in a Chinese population with colorectal cancer precursor lesions. Oncotarget. 7(13):17265-17274, Mar 2016. 

28. Tan Y, Li X, Chen H, Hu Y, Jiang M, Fu J, Yuan Y, Ding K*. Hormone receptor status may impact the survival benefit of surgery in stage iv breast cancer: a population-based study. Oncotarget. 7(43):70991-71000, Oct 2016. 

29. Cai Y, Chen H, He J, Hu Y, Yang Q, Chen L, Xiao Q, Ding K*. The role of surgical intervention in primary colorectal lymphoma: A SEER population-based analysis. Oncotarget. 7(44):72263-72275, Nov 2016. 

30. Xu D, Song R, Wang G, Jeyabal PV, Weiskoff AM, Ding K, Shi ZZ*. Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop. Oncotarget. 2016 Jan 19;7(3):3427-39. doi: 10.18632/oncotarget.6496.