人才队伍

  孙毅，男，医学博士，浙江大学“求是”讲席教授。2020年4月，任浙江大学求是讲席教授。双聘浙江大学医学院附属第二医院肿瘤研究所和转化医学研究院。

科研成果

 孙毅教授长期从事恶性肿瘤发生发展的分子机制，分子标志物/抗肿瘤分子靶点鉴定以及小分子抗癌药物开发的研究工作，在国际上首次克隆了凋亡敏感基因(SAG), 作为CRL（Cullin-RING ligase）E3连接酶的催化核心分子，鉴定了SAG在细胞凋亡, 肿瘤发生, 新生血管形成和干细胞增殖和分化中起到关键的作用。目前正在研发CRL E3连接酶和类泛素化通路的小分子抑制剂。是该研究领域的国际领军者之一。孙毅教授的工作以通讯作者发表于Nature Commun、Science Adv、Mol Cell、Dev Cell、eLife、J Cell Biol、J Clin Invest、PNAS 等国际权威杂志。发表论文累计>230篇，累计他引次数>17000次， H 指数62。获得授权国际专利多项，相关研究获得多项国内外科研基金资助。

学术兼职

 兼任J Biol Chem 等7个国际学术期刊的编委和60多种国际学术期刊的特邀审稿专家。

获奖情况

1. 2000 Alice Hamilton Award for Scientific Excellence, National Institute for Occupational Safety and Health (NIOSH)

2. 2012 Fellow, American Association for the Advancement of Science

3. 2013 Chinese Thousands Talent ProgramYi Sun, MD, PhD.

4. 2018 Co-recipient of Dr. Clyde and Helen Wu Award in International Understanding by the Wu Family China Center for Health Initiatives at the Columbia University, Vagelos College of Physicians and Surgeons.

5. 2019 Lawrence-Krause Research Professor in Radiation Oncology,University of Michig

代表性论文

1. Zhang S, Shen Y, Li H, Bi C, Sun Y, Xiong X, Wei W, Sun Y*. The negative cross-talk between SAG/RBX2/ROC2 and APC/C E3 ligases in regulation of cell cycle progression and drug resistance. Cell Reports. 2020 Sep 8;32(10):108102. 

2. Qiao Y, Yang F, Xie T, Du Z, Zhong D, Qi Y, Li Y, Li W, Lu Z, Rao J, Sun Y*, Zhou M*. Engineered algae: a novel oxygen-generating system for effective cancer treatment. Science Advances 6: eaba5996 20 May 2020. (*Co-corresponding authors)

3. Zhao Y*, Xiong X, Sun Y*. Cullin-RING Ligase 5: Functional Characterization and Its Role in Human Cancers. Semin Cancer Biol. 2020 Apr 22;S1044-579X(20)30085-7. 

4. Yin Y, Xie CM, Li H, Tan M, Chen G, Schiff R, Xiong X, Sun Y*. The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20528-20538.

5. Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, Zhu Y, Sun Y*. Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Protein Cell. 2019 Oct;10(10):726-744.

6. Lan H, Tan M, Li H, Xiong X, Sun Y*. LSD1 destabilizes FBXW7 independent of its demethylase activity via promoting FBXW7 self-ubiquitylation for proteasomal and lysosomal degradation. Proc. Natl. Acad. Sci. USA. 2019 Jun 18;116(25):12311-12320.

7. Yang F, Xu J, Li H, Tan M, Xiong X, Sun Y*. FBXW2 suppresses migration and invasion of lung cancer cells via promoting ubiquitylation and degradation of β-catenin. Nature Communications. 2019 Mar 27;10(1):1382.

8. Xie CM, Tan M, Lin XT, Wu D, Jiang Y, Tan Y, Li H, Ma Y, Xiong X, Sun Y*. The FBXW7-SHOC2-Raptor axis controls the cross-talks between the RAS-ERK and mTORC1 signaling pathways. Cell Reports 2019 Mar 12;26(11):3037-3050.e4.  

9. Zhou Q, Li H, Li Y, Tan M, Fan S, Cao C, Zhu L, Zhao L, Guan M-X, Jin H, Sun Y*. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight. 2019 Feb 21;4(4). pii: 121582.

10. Zhou W, Xu J, Tan M, Zhang J, Li H, Li H, Wei W, Sun Y*. UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F. Mol Cell. 2018 Jun 21;70(6):1008-1024.e6.

11. Zhou W, Xu J, Li H, Xu M, Chen ZJ, Wei W, Pan Z, Sun Y*. Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage.  Clinical Cancer Res. 2017 Feb 15;23(4):1104-1116.

12. Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y*. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications 2017 Jan 16; 8:14002.

13. Zhang Q, Karnak D, Tan M, Lawrence TS, Morgan MA, Sun Y*. FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4. Mol. Cell, 61: 419-433, 2016. 

14. Zhou X, Tan M, Nyati M, Zhao Y, Wang GX, Sun Y*. Blockage of neddylation modification stimulates tumor sphere formation in vitro, and stem cell differentiation and wound healing in vivo. Proc. Natl. Acad. Sci. USA. 2016 May 24;113(21):E2935-44. 

招生信息

        招收肿瘤学方向硕士及博士研究生