人才队伍

    吕志民教授三个原创性里程碑发现，深刻影响了业界对肿瘤代谢的认识, 同时也对开拓新的肿瘤诊治方法提供了创新理论支持:

  1.国际上首次阐明生长因子受体促进 Warburg 效应的分子机制

  2.国际上首次发现多种重要的代谢酶同时具有蛋白激酶活性

  3.国际上率先证实多种代谢酶和代谢产物在肿瘤细胞活动调控中具有重要的非代谢功能, 并因此发现多个肿瘤代谢新靶点

教育背景：

1998 美国纽约市立大学 分子、细胞及发育生物学专业 博士

1986 泰山医学院 临床医学专业 学士

研究工作经历：

2019—至今 浙江大学转化医学研究院 院长

2015—2018 美国德克萨斯大学MD安德森癌症中心Ruby E. Rutherford杰出教授

2013—2018德克萨斯大学安德森癌症中心神经肿瘤学 教授（终身教职）

2009—2013德克萨斯大学安德森癌症中心神经肿瘤学 副教授（终身教职）

2003—2009德克萨斯大学安德森癌症中心神经肿瘤学 助理教授

1999—2003  SALK生物学研究所分子细胞肿瘤学 研究助理/博士后

1993—1999 纽约市立大学研究生院分子细胞肿瘤学 研究助理

1986—1993 青岛医院肿瘤内科 医生

荣誉及奖项：

2019 浙江大学王宽诚杰出讲席教授

2017 美国科学促进会(American Association for the Advancement of Science )会士

2016 美国德克萨斯大学MD安德森癌症中心Dallas/Fort Worth传奇人物基础研究成就奖

2015 美国德克萨斯大学科学技术获得和保留(STARs)奖

2013 美国德克萨斯大学MD安德森癌症中心Potu N. Rao基础科学卓越奖

2012 美国James S. McDonnell基金会学者奖

2011 美国德克萨斯大学MD安德森癌症中心Faculty学者奖

2009 美国癌症协会研究学者奖

2008 美国Peter Steck青年研究者奖

2005 中国科学院王宽诚基金会奖

代表性论著：

1. Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T*. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell, 5/2002, 9(5):945-56, (Highlighted by Nature Review Mol Cell Biol 2002;3:473; Nature-Signaling Update/the signaling gateway, 2002; and Faculty of 1000 Biology).

2. Lu Z*, Ghosh S, Wang Z, Hunter T*. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell, 12/2003, 4(6):499-515 (Highlighted by Nature Review Cancer 2004; 4:90-91; Nature Signaling & Update/The signaling gateway 2004, and Faculty of 1000 Biology).

3. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z*. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.  (Highlighted by Faculty of 1000 Biology; Selected as the feature article by Molecular Cell and received MDACC Nycomed GmbH Outstanding Research Publication Award in 2007). Molecular Cell, 1/2007, 25(2):219-32. PMCID: PMC1829326.

4. Lu Z*, Hunter T*. Degradation of activated protein kinases by ubiquitination. Annual Review Biochemistry, 7/2009, 78:435-75. PMCID: PMC2776765.

5. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, Zhou X, Aldape K, Cobb M, Xie K, He J, and Lu Z*. FAK phosphorylation by ERK primes Ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell, 7/2009, 35(1):11-25 (Highlighted by Molecular Cell and Faculty of 1000 Biology). PMCID: PMC2715139.

6. Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z*. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Molecular Cell, 11/2009, 36(4):547-59 (Selected as the feature article by Molecular Cell and highlighted by Cell and M.D. Anderson News Release). PMCID: PMC2784926.

7. Yang W, Xia X, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z*. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature, 12/2011 480(7375):118-22, PMID: 22056988 (2011 Outstanding Research Publication Award at MD Anderson; Highlighted by Cell, Nature SciBX, Science Signaling, Cancer Research, Cell Research, Chinese journal of Cancer, Future Oncology, and Faculty of 1000 Biology, and M.D. Anderson News Release).

8. Yang W, Xia Y, Hawke D, Li X, Liang J, Aldape K, Hunter T, Yung WK, and Lu Z*. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell, 8/2012; 150 (4): 685-696 (Listed in 2012: Signaling Breakthroughs of the Year, Science Signaling;

Highlighted by Cell, Nature Reviews Cancer, Cancer Discovery, Cell Cycle, Faculty of 1000 Biology, and M.D. Anderson News Release).

9. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You M, Koh M, Cote G, Aldape K, Li Y, Verma I, Chiao P, and Lu Z*. EGFR-induced and PKCe monoubiquitylation-dependent NF-kB activation upregulates PKM2 expression and promotes turmorigenesis. Molecular Cell, 12/2012; 48(5):771-84 PMID:23123196 (Highlighted by Cancer Discovery and M.D. Anderson News Release)

10. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis C, Aldape K, Cantley L, and Lu Z*. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology, 12/2012;14(12):1295-304, PMID:23178880 (Highlighted in Nature Review Cancer 13, 5, 2013; Nature Chemical Biology; Cell Cycle and M.D. Anderson News Release)

11. Jiang Y, Li X, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, and Lu Z*. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Molecular Cell, 1/2014. 53(1):75-87. PMID: 24316223 (Highlighted by Cancer Discovery and M.D. Anderson News Release).

12. Jiang Y, Wang Y, Wang T, Hawke D, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu D, Huang S, and Lu Z*. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells. Nature Communications. 11/2014. 5:5566. (Highlighted by M.D. Anderson News Release).

13. Madarampalli B, Yuan Y, Liu D, Lengel K, Xu Y, Li G, Yang J, Li X, Lu Z, and Liu D*. ATF5 connects the pericentriolar material to the proximal end of the mother centriole in the centrosome. Cell, 7/2015. 162(3):580-92. PMID: 26213385.

14. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin S, and Lu Z*. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology, 9/2015.7(9):1158-68. PMID: 26237645. (highlighted in Nature Cell Biology, Cancer Discovery, Science Signaling, and an MD Anderson news release).

15. Zheng Y, Li X, Qian X, Wang Y, Lee J, Xia Y, Hawke D, Zhang G, Lu J, and Lu Z*. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nature Cell Biology, 10/2015. 17(10):1348-55. PMID: 26280537 (highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).

16.Ji H, Lee J, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z*. EGFR phosphorylates FAM129B to promote Ras activation. PNAS. 1/2016. 113(3):644-9.  PMID:26721396.

17. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, and Lu Z*. Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis. Molecular Cell. 3/2016. 61(5):705-719. PMID:26942675. (highlighted by MD Anderson news release).

18. Li X, Qian X, Peng L, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee J, Cote G, Wang H, Wang L, Qian C, and Lu Z*. A Splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology, 5/2016. 18(5):561-71. PMID:2708854. (Highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).

19. Liang J, Cao R, Zheng Y, Xia Y, Zheng Y, Li X, Wang L, Yang W* and Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 8/2016, 7:12431. PMID: 27485204

20. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z*. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. 3/2017, 2;65(5):917-931.PMID: 28238651 (Highlighted by Autophagy and an MD Anderson news release).

21. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, and Lu Z*. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. The Journal of Experimental Medicine. 6/2017. 214 (6), 1843-1855. PMID:28507061.

22. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, Li W, Lyu J, Rao G, Zhang X, Qian C, Rozen S, Jiang T, Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell. 6/2017;66(5):684-697. PMID:28552616. (Highlighted by Nature Reviews Molecular Cell Biology and an MD Anderson news release).

23. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, Groot J, Tao Jiang T, Lu Z*. Stabilization of Phosphofructokinase 1 Platelet Isoform by AKT Promotes Tumorigenesis. Nature Communications. 10/2017; 16;8(1):949. doi: 10.1038/s41467-017-00906-9. PMID: 29038421

24. Wang Y,Guo Y, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee J, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J He J, Xing D*, Tao Y*, Lu Z*. KAT2A Coupled with the a-KGDH Complex Acts as a Histone H3 Succinyltransferase. Nature, 12/2017. 552(7684):273-277. PMID: 29211711 (Highlighted by Cancer Discovery and an MD Anderson news release).

25. Qian X, Li X, Tan L, Lee JH, Xia X, Cai Q, Zheng Y, Wang H, Lorenzi P, Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery, 1/2018: 8(1):94-107. PMID: 29074724.

26. Lu Z* and Hunter T*. Metabolic Kinases Moonlighting as Protein Kinases. Trends in Biochemical Sciences. 4/2018. (4):301-310. PMID: 29463470.

27. Lee JH, Liu R, Li J., Wang YG, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng y, Chen Q, Lorenzi PL, Mills GB, Jiang T, and Lu Z*. EGFR-phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Molecular Cell, 4/2018 Apr 19;70(2):197-210. PMID: 29677490

28. Li X, Egervari G, Wang Y, Berger SL*, Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology. 9/2018.19(9):563-578. PMID: 29930302

29. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication.  Molecular Cell, 11/2018. 72 (4): 650-660. PMID: 30392930.

30. Xu D, Li X, Shao F, Lv G, Lv H, Lee J, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H*, Lyu J* and Lu Z*. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances, 4/2019. 5 (4): eaav4570. PMID: 31032410.

31. Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z*, Hongxia Wang* (* Co-corresponding). TSPAN8 Promotes Cancer Cell Stemness via Activation of Sonic Hedgehog Signaling. Nature Communications, 6/2019. 10(1):2863. PMID: 31253799.

32. Qian X*, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L,Zheng Y, Zhao D, Zhang C, Lorenzi P, You Y, Jiang B, Jiang T, Li H, and Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Molecular Cell, 11/2019. 76(3):516-527. PMID: 31492635.

33. Xie Y, Lv X, Ni D, Liu J, Hu Y, Liu Y, Liu Y, Liu R, Zhao H, Lu Z*, Zhou Q*(*Co-corresponding). HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nature Communications, 9/2019. 10(1):4266. PMID: 31537781.

34. Qian X*, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Molecular Cell, 12/2019. 76(6):885-895. PMID:31629659

35. Li X*, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, Depinho R, and Lu Z*. Programmable base editing of mutated TERT promoter inhibits tumor growth. Nature Cell Biology, 2/2020. PMID: 32066906 (Highlighted by Nature Cell Biology).

36. Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee J, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung M, and Lu Z*. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature, 4/2020.