研究生教育

        郭江涛，浙江大学“百人计划”研究员，博士生导师，海外高层次人才入选者，研究方向为分子生理与生物物理学。实验室主要采用冷冻电镜、X射线晶体学等生物物理和生物化学方法研究离子通道、离子转运蛋白等膜蛋白的结构生物学。实验室近年来在离子跨膜转运结构生物学领域做出了一系列出色研究成果，以第一作者或通讯作者在国际顶级期刊Nature、Science等杂志发表了多篇重要研究论文。

学习和工作经历

2003.9-2007.6            浙江大学生命科学学院，理学学士

2007.9-2013.6            中国科学院大学（生物物理研究所），生物物理学博士

2013.12-2018.1          美国德州大学西南医学中心/霍华德休斯医学研究院，博士后

2018.1至今                浙江大学医学院/邵逸夫医院，研究员，博士生导师

发表论文(* Corresponding Authors, ^# First Authors)

2018年至今

1.Li X#, Zhang Q#, Guo P#, Fu J, Mei L, Lv D, Wang J, Lai D, Ye S, Yang  H*, Guo J*. Molecular basis for ligand activation of the human KCNQ2 channel. Cell Res doi.org/10.1038/s41422-020-00410-8 (2020).

2. Zhang B#, Jin Q#, Xu L #, Li N #, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N*, Zhang X*, Yang F*, Guo J*, Ye S*. Cooperative transport mechanism of human monocarboxylate transporter 2. Nat Commun 11, 2429 (2020)

3. Jin Q#, Zhang B#, Zheng X#, Li N#, Xu L, Xie Y, Song F, Bhat EA, Chen Y, Gao N, Guo, J*, Zhang X*, Ye S*. Cryo-EM structures of human pannexin 1 channel. Cell Res 30, 449–451 (2020).

4. Delpire E*, Guo J. Cryo-EM structures of DrNKCC1 and hKCC1: a new milestone in the physiology of cation-chloride cotransporters. American Journal of Physiology - Cell Physiology 318(2): C225-C237 (2020).

5. Liu S#, Chang S#, Han B#, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai X*, Guo J*. Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science 366, 505–508 (2019)

6. She J, Zeng W, Guo J, Chen Q, Bai X*, Jiang Y*. Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife. 2019 Mar 12;8. pii: e45222. doi: 10.7554/eLife.45222.

7.She J#, Guo J#, Chen Q#, Zeng W, Jiang Y*, Bai X*. Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130-134 (2018)

2018年之前

8. Guo J#, She J#, Zeng W, Chen Q, Bai X*, Jiang Y*. Structures of the Calcium-activated Non-Selective Cation Channel TRPM4. Nature 552: 205–209 (2017)

9. Chen Q#, She J#, Zeng W, Guo J, Xu H, Bai X*, Jiang Y*. Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature 550:415-418 (2017)

10. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, and Jiang Y*. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature 547: 472-475 (2017)

11. Guo J, Zeng W, Jiang Y*. Tuning the ion selectivity of two-pore channels. Proc Natl Acad Sci USA 114(5):1009-1014 (2017)

12. Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y*. Structure of the voltage-gated two-pore channel from Arabidopsis thaliana. Nature 531:196–201 (2016)

13. Wei X, Guo J, Li M and Liu Z*. Structural mechanism underlying the specific recognition between the Arabidopsis state-transition phosphatase TAP38/PPH1 and phosphorylated light-harvesting complex protein Lhcb1. The Plant Cell 27(4):1113-27 (2015)

14. Guo J, Wei X, Li M, Pan X, Chang W* and Liu Z*. Structure of the catalytic domain of a State transition kinase homolog from Micromonas algae. Protein Cell 4(8):607-19 (2013)