研究生教育

社会任职

MD、PhD、教授/主任医师/博士生导师

浙江大学骨科研究所所长，浙二医院骨科主任

浙江省医学会骨科学分会主委

浙江省骨科重点实验室主任

浙江大学求是特聘医师

中国医师协会骨科医师分会常委

浙江省抗癌协会骨与软组织分会主任委员

浙江省骨科医师协会副会长

中国抗癌协会骨肿瘤与转移瘤专业委员会副主任委员中华医学会骨科分会骨肿瘤学组委员

中国抗癌协会肉瘤专业委员会骨转移瘤学组副组长

中国医师协会骨肿瘤协会四肢工作委员会副组长

《World Journal of Emergency Medicine》副主编，《Surgery》编委，《中华骨科杂志》编委，《JBJS (中文版)》编委，《实用肿瘤杂志》常务编委，《中国骨肿瘤骨病杂志》通讯编委。

科研项目

国家重点研发计划项目1项：牵头，2018年，1246万

国家自然科学基金面上项目4项：主持，2009，30万/2011，54万/2019，57万/2021，55万

浙江省自然科学基金重大项目1项：主持，2021，100万

浙江省自然科学基金一般项目2项：主持，2004，7万/2016，10万

浙江省卫生厅省部共建重点项目：主持，2017，15万

学术成果

在Cancer Research, Cancer Immunology Research，Clinical Orthopaedics and Related Research, , Cell Death and Disease､Frontiers in Immunology等本学科国外核心期刊发表SCI收录论文120余篇，累计影响因子超过150。在《中华骨科杂志》本学科国内核心期刊发表文章17篇。

1. Wang Y,Teng W,Zhang Z,Zhou X, Ye Y,Lin P,Liu A,Wu Y,Li B, Li W, Yu X, Gou Z,Ye Z.A Trilogy Antimicrobial Strategy for Multiple Infections of Orthopedic Implants throughout Their Life Cycle. Bioactive Materials 2020.（叶招明，通讯作者，接收）

2. Li H, Gao J, Gao Y, Lin N, Zheng M, Ye Z. Denosumab in Giant Cell Tumor of Bone: Current Status and Pitfalls. Front Oncol 2020.（叶招明，通讯作者）

3. Chen T, Guo J, Cai Z, Li B, Sun L, Shen Y, Wang S, Wang Z, Wang Z, Wang Y, Zhou H, Cai Z, Ye Z.Th9 Cell Differentiation and Its Dual Effects in Tumor Development. Front Immunol 2020.（叶招明，通讯作者）

4. Lin P, Yang PF, Chen S, Shao YY, Xu L, Wu Y, Teng W, Zhou XZ, Li BH, Luo C, Xu LM, Huang M, Niu TY, Ye ZM. A Delta-radiomics model for preoperative evaluation of Neoadjuvant chemotherapy response in high-grade osteosarcoma.Cancer Imaging 2020.（叶招明，通讯作者）

5. Wang Z, Wang Z, Li B, Wang S, Chen T, Ye Z. Innate Immune Cells: A Potential and Promising Cell Population for Treating Osteosarcoma.Front Immunol 2020.（叶招明，通讯作者）

6. Li B, Wang Z, Wu H, et al. Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma. Cancer Res 2018. （叶招明，通讯作者）

7. Lin Nong, Li Hengyuan, Li Weixu, etc. Upshifting the Ipsilateral Proximal Femur May Provide Satisfactory Reconstruction of Periacetabular Pelvic Bone Defects After Tumor Resection. Clin Orthop Relat Res 2018. （叶招明，通讯作者）

8. Sun LL, Ren SH, Li BH, Li HY, Huang X, Ye ZM. Letter to the Editor: Immune Surveillance Plays a Role in Locally Aggressive Giant Cell Lesions of Bone. Clin Orthop Relat Res 2018. （叶招明，通讯作者）

9. Wu Y, Xu L, Yang P, et al. Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography. EBioMedicine. 2018. （叶招明，通讯作者）

10. Wang Z, Wang ZA, Li S, et al. Decitabine Enhances V gamma 9V delta 2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL-NKG2D Axis. Front Immunol 2018. （叶招明，通讯作者）

11. Wang S, Li H, Ye C, et al. Valproic Acid Combined with Zoledronate Enhance gammadelta T Cell-Mediated Cytotoxicity against Osteosarcoma Cells via the Accumulation of Mevalonate Pathway Intermediates. Front Immunol 2018; 9: 377. （叶招明，通讯作者）

12. Ren S, Wang Z, Huang X, Sun L, Shao J, Ye Z. Prognostic factors for postoperative survival among patients with rhabdomyosarcoma of the limbs. Cancer Manag Res 2018; 10: 4181-9. （叶招明，通讯作者）

13. Teng W, Lin P, Li Y, et al. Bone combined cement grafting in giant cell tumor around the knee reduces mechanical failure. Int Orthop 2018. （叶招明，通讯作者）

14. Lin P, Lin N, Teng W, et al. Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases. Orthop Surg 2018; 10(2): 107-14. （叶招明，通讯作者）

15. Wang Z, Li S, Li Y, et al. Prognostic factors for survival among patients with primary bone sarcomas of small bones. Cancer Manag Res 2018; 10: 1191-9. （叶招明，通讯作者）

16. Pan W, Feng B, Wang Z, Lin N, Ye Z. Malignant peripheral nerve sheath tumor in the paraspinal region mimicking a benign peripheral nerve sheath tumor: a case report. Eur Spine J 2017; 26(Suppl 1): 90-4. （叶招明，通讯作者）

17. Wang Z, Ye Z. Comment on Dumbbell Scoring System: A New Method for the Differential Diagnosis of Malignant and Benign Spinal Dumbbell Tumors. Spine (Phila Pa 1976) 2017; 42(3): E191. （叶招明，通讯作者）

18. Li B, Zhu X, Sun L, Yuan L, Zhang J, Li H, Ye Z. Induction of a specific CD8+ T-cell response to cancer/testis antigens by demethylating pre-treatment against osteosarcoma. Oncotarget. 2014. Nov 15;5(21):10791-802（叶招明，通讯作者）

19. Li HY, Zhang J, Sun LL, Li BH, Gao HL, Xie T, Zhang N, Ye ZM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study. Cell Death Dis. 2015; 6: e1604（叶招明，通讯作者）

20. Sun L, Li Y, Jiang Z, Zhang J, Li H, Li B, et al. Vgamma9Vdelta2 T cells and zoledronate mediate antitumor activity in an orthotopic mouse model of human chondrosarcoma. Tumour Biol 2015. （叶招明，通讯作者）

21. Liu M, Sun LL, Li YJ, Li HY, Zhang J, Li BH, et al. Trastuzumab enhanced the cytotoxicity of Vgamma9Vdelta2 T cells against zoledronate-sensitized osteosarcoma cells. Int Immunopharmacol 2015. （叶招明，通讯作者）

22. Zhang N, Ying MD, Wu YP, Zhou ZH, Ye ZM, Li H, et al. Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cells. PLoS One. 2014; 9(7): e98973. （叶招明，通讯作者）

23. Zhang J, Zhu X, Li H, Li B, Sun L, Xie T, Ye ZM. Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression. Int Immunopharmacol. 2015 Jan;24(1):50-8. （叶招明，通讯作者）

24. Sun L, Li Y, Zhang J, Li H, Li B, Ye Z. Prognostic value of pathologic fracture in patients with high grade localized osteosarcoma: A systemic review and meta-analysis of cohort studies. J Orthop Res. 2015 Jan;33(1):131-9 （叶招明，通讯作者）

25. Sun L, Li Y, Li H, Zhang J, Li B, Ye Z. Analysis of chemotherapy dosage and dosage intensity and survival outcomes of high-grade osteosarcoma patients younger than 40 years. Clin Ther. 2014; 36(4): 567-78. （叶招明，通讯作者）

26. Li B, Ye Z. Epigenetic alterations in osteosarcoma: promising targets. Molecular Biology Reports. 2014 May;41(5):3303-15. （叶招明，通讯作者）

27. Pan W, Wang H, Jianwei R, Ye Z. MicroRNA-27a Promotes Proliferation, Migration and Invasion by Targeting MAP2K4 in Human Osteosarcoma Cells. Cell Physiol Biochem. 2014; 33(2): 402-12. （叶招明，通讯作者）

28. Li Z, Peng H, Xu Q, Ye Z. Sensitization of human osteosarcoma cells to Vgamma9Vdelta2 T-cell-mediated cytotoxicity by zoledronate. J Orthop Res. 2012; 30(5): 824-30. （叶招明，通讯作者）

29. Li Z, Xu Q, Peng H, Cheng R, Sun Z, Ye Z. IFN-gamma enhances HOS and U2OS cell lines susceptibility to gammadelta T cell-mediated killing through the Fas/Fas ligand pathway. Int Immunopharmacol. 2011; 11(4): 496-503. （叶招明，通讯作者）

获奖情况

获浙江省科技厅二等奖1项

获浙江省科技厅三等奖1项

浙江省卫生厅一等奖1项