tutor

导师介绍

钱玲慧

研究员 | 博士生导师

浙江大学药学院研究员

电话

邮箱

lhqian@zju.edu.cn

地址

浙江大学药学院223室

个人简介

课题组主要研究方向为：

1. 探索疾病相关生物标记并构建高性能荧光探针对其进行检测

2. 开发新型有机小分子/生物大分子制剂对病理状态进行调控

3. 研究药物/活性化合物的靶点和作用机制

4. 揭示疾病机理并优化疾病早期诊断


招贤纳才

  课题组热忱欢迎访问学者、博士后、研究生和本科生等有志之士的加盟和交流合作！



2018.11 至今： 浙江大学药学院，“百人计划”研究员、博士生导师

2017.9-2018.9：新加坡科技局分子与细胞生物学研究院（IMCB，A*STAR），博士后 （导师：SONG Haiwei 教授）

2017.1-2017.8：新加坡国立大学，化学系，研究助理 （导师：YAO Shao Qin 教授）

2013.1-2017.5：新加坡国立大学，化学生物学，博士（导师：YAO Shao Qin 教授）

2008.9-2012.6：浙江大学，药学，学士（导师：曾苏 教授）


研究成果：

  1. Kong, Y.; Zeng, K.; Zhang, Y.; Shao, J.; Yan, J.; Liao, J.-Y.; Wang, W.; Dai, X.; Weng, Q.; Yao, S. Q.; Zeng, S.;* Qian, L.* In vivo targeted delivery of antibodies into cancer cells with pH-responsive cell-penetrating poly(disulfide)s, Chem. Commun. 2022, 58, 1314-1317. 

    https://pubs.rsc.org/en/content/articlelanding/2022/cc/d1cc06840g

  2. Wang, W.;# Zhang, Y.;# Zhao, H.;# Zhuang, X.; Wang, H.; He, K.; Xu, W.; Kang, Y.; Zeng, S.; Qian, L.* Real-Time Imaging of Cell-Surface Proteins with Antibody-Based Fluorogenic Probes, Chem. Sci. 2021, 12, 13477-13482. (# These authors contributed equally to this work.) 

    https://pubs.rsc.org/en/content/articlelanding/2021/sc/d1sc03065e#!

  3. Qian, L.;# Tao, L.-F.;# Wang, W.-T.; Jameel, E.; Luo, Z.-H.; Zhang, T.; Zhao, Y.; Liao, J.-Y. Catalytic Atroposelective Dynamic Kinetic Resolution of Biaryl Lactones with Activated Isocyanides, Org. Lett. 2021, 23, 5086-5091. (# These authors contributed equally to this work.) 

    https://pubs.acs.org/doi/10.1021/acs.orglett.1c01632

  4. Zhu, Y.; Liao J.-Y.;* Qian L.* Isocyanides: promising functionalities in bioorthogonal labeling of biomolecules, Front. Chem. 2021, 670751. 

    https://www.frontiersin.org/articles/10.3389/fchem.2021.670751/full

  5. He, K.; Zeng, S.; Qian, L.* Recent Progress in the Molecular Imaging of Therapeutic Monoclonal Antibodies, J. Pharm. Anal. 2020, 10, 397-413. Selected as cover picture. 

    https://linkinghub.elsevier.com/retrieve/pii/S2095177920310261

  6. Qian, L.; * Yao, S. Q. Preface for the Special Issue on Analysis of Drug or Drug Targets by Molecular Imaging, J. Pharm. Anal. 2020, 10, iii-iv. 

    https://linkinghub.elsevier.com/retrieve/pii/S2095177920310613

  7. 钱玲慧; 蔡圣; 余露山; 曾苏* 国家自然科学基金批准资助药物分析项目分析,药物分析杂志 2020, 40, 759-766.

    http://ywfxzz.yywkt.com/Magazine/Show/145187

  8. Lang, W.; Yuan, C.; Zhu, L.; Du, S.; Qian, L.; Ge, J.;* Yao, S. Q.* Recent advances in construction of small molecule-based fluorophore-drug conjugates, J. Pharm. Anal. 2020, 10, 434-443. 

    https://linkinghub.elsevier.com/retrieve/pii/S2095177920310467

  9. Dong, J.; Hong, D.; Lang, W.; Huang, J.; Qian, L.; Zhu, Q.;* Li, L.; Ge, J.* Different Tagged Probes for Protein Profiling of Mitochondria, ChemBioChem 2019, 20, 1155-1160. 

    https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201800735

  10. Shi, R.;# Wu, Q.;# Xin, C.; Yu, H.; Lim, K.-L.; Li, X.; Shi, Z.; Zhang, C.-W.;* Qian, L.; Li, L.;* Huang, W. Structure-Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases, ChemBioChem 2019, 20, 1487-1497. (# These authors contributed equally to this work.) 

    https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.201800813

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Before ZJU

  

  1. Qian, L.;* Pan, S.; Lee, J.-S.; Ge, J.; Li, L.;* Yao, S. Q.* Live-cell Imaging and Profiling of c-Jun N-terminal Kinases Using Covalent Inhibitor-derived Probes, Chem. Commun. 2019, 55, 1092-1095.

  2. Qian, L.;# Fu, J.; # Yuan, P.; Du, S.; Huang, W.; Li, L.;* Yao, S. Q.* Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s, Angew. Chem. Int. Ed. 2018, 57, 1532-1536. (# These authors contributed equally to this work.) Selected as cover picture (Angew. Chem. Int. Ed. 2018, 57, 1421).

  3. Qian, L.; Zhang, C.-J.; Wu, J.; Yao, S. Q.* Fused Bicyclic Caspase-1 Inhibitors Assembled by Copper-Free Strain-Promoted Alkyne-Azide Cycloaddition (SPAAC), Chem. Eur. J. 2017, 23, 360-369.

  4. Qian, L.; Li, L.;* Yao, S. Q.* Two-Photon Small Molecule Enzymatic Probes, Acc. Chem. Res. 2016, 49, 626-634.

  5. Qian, L.; Zhang, C.-W.; Mao, Y.; Li, L.; Gao, N.; Lim, K.-L.; Xu, Q.-H.; Yao, S. Q.* Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models, Sci. Rep. 2016, 6, 26385.

  6. Yuan, P.; Zhang, H.; Qian, L.; Mao, X.; Du, S.; Yu, C.; Peng, B.; Yao, S. Q.* Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher, Angew. Chem. Int. Ed. 2017, 56, 12481-12485.

  7. Yu, C.; Qian, L.; Ge, J.; Fu, J.; Yuan, P.; Yao, S. C. L.; Yao, S. Q.* Cell-Penetrating Poly(disulfide) Assisted Intracellular Delivery of Mesoporous Silica Nanoparticles for Inhibition of miR-21 Function and Detection of Subsequent Therapeutic Effects, Angew. Chem. Int. Ed. 2016, 55, 9272-9276.

  8. Li, Z.; Qian, L.; Li, L.; Bernhammer, J. C.; Huynh, H. V.; Lee, J.-S.; Yao, S. Q.* Tetrazole Photoclick Chemistry: Reinvestigating Its Suitability as a Bioorthogonal Reaction and Potential Applications, Angew. Chem. Int. Ed. 2016, 55, 2002-2006.

  9. Yu, C.; Qian, L.; Uttamchandani, M.; Li, L.; Yao, S. Q.* Single-Vehicular Delivery of Antagomir and Small Molecules to Inhibit miR-122 Function in Hepatocellular Carcinoma Cells by Using “Smart” Mesoporous Silica Nanoparticles, Angew. Chem. Int. Ed. 2015, 54, 10574-10578. Selected as hot paper.

  10. Li, L.; # Zhang, C-W.; # Ge, J.; # Qian, L.; Chai, B.-H.; Zhu, Q.; Lee, J.-S.; Lim, K.-L.; Yao, S. Q.* A Small Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease, Angew. Chem. Int. Ed. 2015, 54, 10821-10825. (# These authors contributed equally to this work.) Selected as hot paper.

  11. Liu, P.; Li, S.; Jin, Y.; Qian, L.; Gao, N.; Yao, S. Q.; Huang, F.;* Xu, Q.-H.;* Cao, Y. Red-Emitting DPSB-Based Conjugated Polymer Nanoparticles with High Two-Photon Brightness for Cell Membrane Imaging, ACS Appl. Mater. Interfaces 2015, 7, 6754-6763.

  12. Li, X.; Yu, J.; Zhu, Q.;* Qian, L.; Li, L.; Zheng, Y.;* Yao, S. Q.* Visualization of Monoamine Oxidases in Living Cells Using “Turn-ON” Fluorescence Resonance Energy Transfer Probes, Analyst 2014, 139, 6092-6095.

  13. Qian, L.; Liao, J.; Li, Y.; Mo, X.; Ma, L.; Yao, T.* Comparison of Three Methods on Assay for Vitamin A: UV, NP-HPLC and RP-HPLC, Experimental Technology and Management 2012, 5, 43-48. (Undergraduate)




研究方向

  • · 药学

  • · 化学生物学


电话：0571-87073105 邮箱：0920140@zju.edu.cn 地址：浙江省杭州市余杭塘路866号