研究生教育

孙启明，浙江大学基础医学院教授。

研究与成果：长期从事膜生物学研究，在膜性细胞器的结构和功能研究领域取得一系列重要原创性成果。代表性成果包括：1. 鉴定了Barkor/Atg14L，阐明Barkor-PI3KC3在自噬体形成中的重要功能以及作用机制；2. 发现并克隆了Pacer，揭示其在自噬体和溶酶体融合中的作用和活性调控机制；3. 揭示了自噬体与高尔基体和内质网的互作分子基础及其生理和病理意义；4. 鉴定了模式识别受体NOD1/2分子定位于内体膜和细胞膜，感知病原细菌侵染的天然免疫机制。以第一作者或通讯作者发表研究论文16篇；近五年发表的代表性通讯作者论文（含共同）包括Molecular Cell (2017, 2019)、Science (2019)、EMBO J (2020)和Autophagy (2019)。孙启明的研究成果被EMBO J杂志专题论文评价、被Faculty1000收录并推荐、被Autophagy杂志邀请专文评述。

代表性论文：

1. Lu Y*, Zheng Y*, Coyaud É*, Zhang C*, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD#, Raught B#, Sun Q#, Neculai D#. Palmitoylation of NOD1 and NOD2 is required for bacterial sensing. Science. 2019 Oct 25; 366(6464):460-467.

2. Jiang X*, Wang X*, Ding X*, Wong X, Zhang J, Li L, Ding X, Tian R, Zhu Q, Chen S, Liu W, Fang L#, Neculai D#, Sun Q#. FAM134B oligomerization drives ER scission for ER-phagy. EMBO J. 2020 Jan 13: e102608.

3. Liu C, Cheng X, Chen J, Wang Y, Wu X, Tian R, Liu B, Ding X, Sun Q#, Gong W#. Suppression of YAP/TAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration. Theranostics. 2019 May 31;9(13):3840-3852.

4. Cheng X, Ma X, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q#. Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism. Mol Cell. 2019 Feb 21;73(4):788-802.

5. Ding X, Jiang X, Tian R, Zhao P, Li L, Wang X, Chen S, Zhu Y, Mei M, Bao S, Liu W, Tang Z#, Sun Q#. RAB2 regulates the formation of autophagosome and autolysosome in mammalian cells. Autophagy. 2019 Oct;15(10):1774-1786.

6. Su H, Yang F, Wang Q, Shen Q, Huang J, Peng C, Zhang Y, Wan W, Wong CCL, Sun Q, Wang F, Zhou T, Liu W. VPS34 Acetylation Controls Its Lipid Kinase Activity and the Initiation of Canonical and Non-canonical Autophagy. Molecular Cell. 2017;67(6):907-921.

7. Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, et al. (2017). MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy, 1-16.

8. Cheng X, Ma X, Ding X, Li L, Jiang X, Shen Z, Chen S, Liu L, Gong W#, Sun Q#. Pacer mediates the function of Class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17. Mol Cell. 2017 Mar 16;65(6):1029-1043.

9. Yan X*, Sun Q*, Ji J, Zhu Y, Liu Z, Zhong Q#. Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy. 2012 Feb 1;8(2):213-21.

10. Sun Q, Zhang J, Fan W, Wong KN, Ding X, Chen S, Zhong Q#. The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J Biol Chem. 2011 Jan 7;286(1):185-91.

11. Sun Q, Westphal W, Wong KN, Tan I, Zhong Q#. Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19338-43.

12. Sun Q, Fan W, Chen K, Ding X, Chen S, Zhong Q#. Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19211-6.

招生信息：生物化学方向硕士、博士