研究生教育

叶学松，浙江大学生物医学工程与仪器科学学院教授，博导，浙江大学医学院附属邵逸夫医院兼聘教授。浙江大学医疗健康信息工程技术研究所所长，浙江省智能诊疗设备制造业创新中心执行主任，浙江省腔镜技术研究重点实验室副主任。1997年浙江大学生物医学工程专业博士毕业，历任讲师、副教授和教授（2005年），2006~2008年前往美国Case Western Reserve University电子工程系访问合作。

研究与成果：长期从事传感检测技术和科学仪器研发等方面科研工作，发表学术论文100余篇，SCI/EI80余篇；获国家发明专利20余项；2013全军科技进步一等奖1项，2002、2013浙江省科技进步奖各1项；国家医疗器械产品注册证3项。致力于微创手术器械（高端电子内窥镜/微创手术导航系统）、健康监测设备（穿戴/非接触式）、体外诊断试剂（POCT）和运动康复等医疗器械研发和成果转化。

以生物信息获取为目标，紧密结合基础与临床的医学需求，分别在分子、细胞、组织和系统的水平上，着重开展生物医学传感器的微纳制造、CMOS集成电路低功耗接口设计、检测系统微型化封装及其智能化检测技术研究，研发面向重大疾病诊疗的医学仪器和医疗器械。课题组目前研究方向有：1）生物化学传感检测技术、微流体生物芯片及相关体外诊断试剂医疗器械研发；2）非接触式、穿戴式无线人体生理参数检测技术及相关健康监测和运动康复等医疗器械研发；3）微创手术器械、高端电子内窥镜、手术精准导航和机器人系统。

主要在研基金项目：

1. 多模态影像融合肝脏微创手术导航仪器系统的研发，国家自然科学基金重大科研仪器研制项目，2019-2023。

2. 医用CMOS 专用图像处理通用模块研发，国家重点研发计划， 2019-2021。

3. 超高清胸、腹腔镜系统及超细径电子肾盂软镜系统研发，浙江省重点研发计划，2018-2020。

代表性论文：

1. Yu Cai, Bo Liang*, Shidie Chen, Qin Zhu, Tingting Tu, Ke Wu, Qingpeng Cao, Lu Fang, Xiao Liang, Xuesong Ye*. One-step modification of nano-polyaniline/glucose oxidase on double-side printed flexible electrode for continuous glucose monitoring: Characterization, cytotoxicity evaluation and in vivo experiment. Biosensors and Bioelectronics, 2020，112408.

2. Congcong Yu, Qingpeng Cao, Tingting Tu, Yu Cai, Lu Fang, Xuesong Ye*, Bo Liang*, Differential coulometry based on dual screen-printed strips for high accuracy levodopa determination towards Parkinson's disease management, Journal of Pharmaceutical and Biomedical Analysis, 2020, 113498

3. Qingpeng Cao, Bo Liang*, Congcong Yu, Lu Fang, Tingting Tu, Jinwei Wei, Xuesong Ye*, High accuracy determination of multi metabolite by an origami-based coulometric electrochemical biosensor, Journal of Electroanalytical Chemistry, 2020, 114358.

4. Bo Liang, Qingpeng Cao, Xiyu Mao, Wenhao Pan, Tingting Tu, Lu Fang, Xuesong Ye*, An Integrated Paper-based Microfluidic Device for Real-time Sweat Potassium Monitoring, IEEE Sensors Journal, 2020, doi: 10.1109/JSEN.2020.3009327.

5. Qingpeng Cao, Bo Liang*, Xiyu Mao, Jinwei Wei, Tingting Tu, Lu Fang, Xuesong Ye*, A Smartwatch Integrated with a Paper‐based Microfluidic Patch for Sweat Electrolytes Monitoring, Electroanalysis, 2020, doi:10.1002/elan.202060025.

6. Zhou, J., Tu, C., Liang, Y., Huang, B., Fang, Y., Liang, X., & Ye, X*. (2020). The label-free separation and culture of tumor cells in a microfluidic biochip. Analyst, 145(5), 1706-1715.

7. Bobo Huang, Bin Zhang, Bo Liang*, Lu Fang and Xuesong Ye*, Ultra-low level detection of hepatocellular carcinoma global methylation using a AuNP modified carbon fiber microelectrode. RSC Advances, 2020, 10(28): 16277-16283.

8. Tingting Tu, Bo Liang*, Qingpeng Cao, Lu Fang, Qin Zhu, Yu Cai,  Xuesong Ye*, Fully transient electrochemical testing strips for eco-friendly point of care testing. RSC Advances, 2020, 10(12): 7241-7250.

9. Qin Zhu, Bo Liang*, Yitao Liang, Lin Ji, Yu Cai, Ke Wu, Tingting Tu, Hangxu Ren, Bobo Huang, Jinwei Wei, Lu Fang, Xiao Liang, Xuesong Ye*, 3D bimetallic Au/Pt nanoflowers decorated needle-type microelectrode for direct in situ monitoring of ATP secreted from living cells. Biosensors and Bioelectronics, 2020, 112019.

10. Jinwei Wei, Bo Liang*, Qingpeng Cao, Hangxu Ren, Youming Zheng, Xuesong Ye*, Understanding asymmetric transfer characteristics and hysteresis behaviors in graphene devices under different chemical atmospheres, Carbon, 2020, 156, 67-76.

11. Bo Liang, Jinwei Wei, Lu Fang, Qingpeng Cao, Tingting Tu, Hangxu Ren, and Xuesong Ye*, High-Resolution Rapid Prototyping of Liquid Metal Electronics by Direct Writing on Highly Prestretched Substrates, ACS Omega, 2019, 4, 25, 21072-21077.

12. Qingpeng Cao, Bo Liang*, Tingting Tu, Jinwei Wei, Lu Fang and  Xuesong Ye*. Three-dimensional paper-based microfluidic electrochemical integrated devices (3D-PMED) for wearable electrochemical glucose detection, RSC Advances, 2019, 9: 5674-5681.

13. Lu Fang, Qin Zhu, Yu Cai, Bo Liang*, Xuesong Ye*, 3D porous structured polyaniline/reduced graphene oxide/copper oxide decorated electrode for high performance nonenzymatic glucose detection, Journal of Electroanalytical Chemistry, 2019, 841:1-9.

14. Bobo Huang, Lin Ji, Bo Liang*, Qingpeng Cao, Tingting Tu and  Xuesong Ye*. A simple and low-cost screen printed electrode for hepatocellular carcinoma methylation detection, Analyst, 2019,144: 3282-3288.

15. Li W., Li S., Shen L., Wang J., Wu X., Li J., Tu C., Ye X* & Ling, S. (2019). Impairment of dendrodendritic inhibition in the olfactory bulb of APP/PS1 mice. Frontiers in Aging Neuroscience, 11, 2.

16. Liang B, Ye X*. Towards high-density recording of brain-wide neural activity[J]. Science China Materials, 2018, 61(3): 432-434.

17. Zhou J, Tu CL, Liang YT, Huang BB, Fang YF, Liang X, Papautsky I, Ye X*.Isolation of cells from whole blood using shear-induced diffusion[J].SCIENTIFIC REPORTS, 2018,8: 1-13.

18. Zhu Q, Liang B, Cai Y, Cao Q, Tu T, Huang B, Fang L, Ye X*. Layer-by-layer chitosan-decorated pristine graphene on screen-printed electrodes by one-step electrodeposition for non-enzymatic hydrogen peroxide sensor[J]. Talanta, 2018, 190: 70-77.

19. Feng J, Huang Z, Zhou C, Ye X*. Study of continuous blood pressure estimation based on pulse transit time, heart rate and photoplethysmography-derived hemodynamic covariates[J]. Australasian physical & engineering sciences in medicine, 2018, 41(2): 403-413.

20. Ji Q, Wang F, Zhou R, Li J, Wang J, Ye X*. Assessment of ankle muscle activation by muscle synergies in healthy and post-stroke gait[J]. Physiological measurement, 2018, 39(4): 045003.

21. Fang L, Liang B, Yang G, Hu Y, Zhu Q, Ye X*. A needle-type glucose biosensor based on PANI nanofibers and PU/E-PU membrane for long-term invasive continuous monitoring[J]. Biosensors and Bioelectronics, 2017, 97: 196-202.

22. Feng J, Zhou C, He C, Li Y, Ye X*. Development of an improved wearable device for core body temperature monitoring based on the dual heat flux principle[J]. Physiological measurement, 2017, 38(4): 652. SCI, 2.068

23. Tu C, Zhou J, Liang Y, Huang B, Fang Y, Liang X, Ye X*. A flexible cell concentrator using inertial focusing[J]. Biomedical microdevices, 2017, 19(4): 83.

24. Liang B, Zhu Q, Fang L, Cao Q, Liang X, Ye X*. An origami paper device for complete elimination of interferents in enzymatic electrochemical biosensors[J]. Electrochemistry Communications, 2017, 82: 43-46.

25. Wei J, Liang B, Cao Q,  Mo C, Zheng Y, Ye X*. Vertically aligned PANI nanorod arrays grown on graphene oxide nanosheets for a high-performance NH 3 gas sensor[J]. RSC Advances, 2017, 7(53): 33510-33520.

26. Tian J, Tu C, Huang B, Liang Y, Zhou J, Ye X*. Study of the union method of microelectrode array and AFM for the recording of electromechanical activities in living cardiomyocytes[J]. European Biophysics Journal, 2017, 46(5): 495-507.

27. Hu Y, Liang B, Fang L, Ma G, Yang G, Zhu Q, Chen S, Ye X*. Antifouling zwitterionic coating via electrochemically mediated atom transfer radical polymerization on enzyme-based glucose sensors for long-time stability in 37 C serum[J]. Langmuir, 2016, 32(45): 11763-11770.

28. Zhou C, Feng J, Hu J, Ye X*. Study of artifact-resistive technology based on a novel dual photoplethysmography method for wearable pulse rate monitors[J]. Journal of medical systems, 2016, 40(3): 56.

29. Yang G, Liang B, Zhu Q, Hu Y, Ye X*. Comprehensive study of the effects of nanopore structures on enzyme activity for the enzyme based electrochemical biosensors based on molecular simulation[J]. The Journal of Physical Chemistry A, 2016, 120(50): 10043-10056.

30. Tu C, Huang B, Zhou J, Liang Y, Tian J, Ji L, Liang X, Ye X*. A microfluidic chip for cell patterning utilizing paired microwells and protein patterns[J]. Micromachines, 2016, 8(1): 1.

31. Huang B, Yin M, Zhang A P, Ye X*. On-chip microfabrication of thermally controllable PNIPAAm microvalves by using optical maskless stereolithography[J]. Sensors and Actuators A: Physical, 2016, 247: 397-402.

32. Zheng Q, Chen L, Lu L, Ye X*. A review of olfactory cell-based sensors: coupling microelectronics to olfactory cells[J]. Sensor Review, 2016, 36(4): 446-455.

33. Liang B, Guo X, Fang L, Hu Y, Yang G, Zhu Q, Wei J, Ye X*. Study of direct electron transfer and enzyme activity of glucose oxidase on graphene surface[J]. Electrochemistry Communications, 2015, 50: 1-5.

34. Hu Y, Yang G, Liang B, Fang L, Ma G, Zhu Q, Chen S, Ye X*. The fabrication of superlow protein absorption zwitterionic coating by electrochemically mediated atom transfer radical polymerization and its application[J]. Acta biomaterialia, 2015, 13: 142-149.

35. Tian J, Tu C, Liang Y, Zhou J, Ye X*. Study of laser uncaging induced morphological alteration of rat cortical neurites using atomic force microscopy[J]. Journal of neuroscience methods, 2015, 253: 151-160.

36. Zhou C, Tu C, Tian J, Feng J, Gao Y, Ye X*. A low power miniaturized monitoring system of six human physiological parameters based on wearable body sensor network[J]. Sensor Review, 2015, 35(2): 210-218.

37. Liang B, Fang L, Hu Y, Yang G, Zhu Q, Ye X*. Fabrication and application of flexible graphene silk composite film electrodes decorated with spiky Pt nanospheres. Nanoscale, 2014, 6(8): 4264-4274.

38. Fang L, Liang B, Yang G, Hu Y, Zhu Q, Ye X*. Study of glucose biosensor lifetime improvement in 37 C serum based on PANI enzyme immobilization and PLGA biodegradable membrane[J]. Biosensors and Bioelectronics, 2014, 56: 91-96.

39. Guo X, Liang B, Jian J, Zhang Y, Ye X*. Glucose biosensor based on a platinum electrode modified with rhodium nanoparticles and with glucose oxidase immobilized on gold nanoparticles[J]. Microchimica Acta, 2014, 181(5-6): 519-525.

40. Liang B, Fang L, Yang G, Hu Y, Guo X, Ye X*. Direct electron transfer glucose biosensor based on glucose oxidase self-assembled on electrochemically reduced carboxyl graphene[J]. Biosensors and Bioelectronics, 2013, 43: 131-136. 

41. Yang G, Kang Z, Ye X*, Wu T, Zhu Q. Molecular simulation of flavin adenine dinucleotide immobilized on charged single-walled carbon nanotubes for biosensor applications[J]. Biomaterials, 2012, 33(34): 8757-8770.

42. Ying N, Tian J, Yu S N, Zhou J, Ling S, Xia L, Ye X*. Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb[J]. Science China Life Sciences, 2012, 55(7): 567-575.

43. Ye X, Zeng Y, Zhou T, Liu F, Liu J, Sha J, Xu X, Xia L. In Situ Comparative Studies of Self-Assembly Adsorption of Bovine Serum Albumin on Nano Films by Atomic Force Microscopy[J]. Journal of nanoscience and nanotechnology, 2011, 11(12): 10765-10769.

44. Ye X*, Wang X, Liang B, Wang Q, He L, Bei W. Implantable passive and wireless telemetering system based on SAW temperature sensor[J]. Journal of Zhejiang University. Engineering Science, 2011, 45(11): 2068-2072.

45. Ye X*, Fang L, Liang B,  Wang Q, Wang X, He L, Bei W, Ko W. H. Studies of a high-sensitive surface acoustic wave sensor for passive wireless blood pressure measurement[J]. Sensors and Actuators A: Physical, 2011, 169(1): 74-82.

46. Ling S, Gao T, Liu J, Li Y, Zhou J, Li J, Zhou C, Tu C, Han F, Ye X*. The fabrication of an olfactory receptor neuron chip based on planar multi-electrode array and its odor-response analysis[J]. Biosensors and Bioelectronics, 2010, 26(3): 1124-1128.

47. Lu L, Xia L, Ye X*. Cheng H. Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure[J]. Physical biology, 2010, 7(2): 026005.

48. Ko W H, Zhang R, Huang P,  Guo J, Ye X, Young D J, Megerian C. A. Studies of MEMS acoustic sensors as implantable microphones for totally implantable hearing-aid systems[J]. IEEE transactions on biomedical circuits and systems, 2009, 3(5): 277-285.

49. Liu F, Ye X*， Wu T, Wang C, Shen J, Kang Y. Conformational mobility of gox coenzyme complex on single-wall carbon nanotubes[J]. Sensors, 2008, 8(12): 8453-8462.

50. Ye X, Wang P, Liu J,  Zhang S, Jiang J, Wang Q, Zheng X*. A portable telemetry system for brain stimulation and neuronal activity recording in freely behaving small animals[J]. Journal of Neuroscience Methods, 2008, 174(2): 186-193.

51. Feng Z, Chen W, Ye X, Zhang S, Zheng X, Wang P, Jiang J, Jin L, Xu Z, Liu C, Liu F, Luo J, Zhuang Y, Zheng X. A remote control training system for rat navigation in complicated environment, Source: Journal of Zhejiang University: Science A, v 8, n 2, p 323-330, February 2007.

52. Men H, Zou S, Li Y, Wang Y, Ye X, Wang P. A novel electronic tongue combined MLAPS with stripping voltammetry for environmental detection. Source: Sensors And Actuators, B: Chemical, v 110, n 2, p 350-357, October 14, 2005  

53. Xu G, Ye X, Qin L, Xu Y, Li Y, Li R, Wang P. Cell-based biosensors based on light-addressable potentiometric sensors for single cell monitoring. Source: Biosensors & Bioelectronics, v 20, n 9, p 1757-1763, March 15, 2005

54. He H, Xu G, Ye X, Wang P.A novel chemical image sensor consisting of integrated microsensor array chips and pattern recognition. Source: Measurement Science and Technology, v 14, n 7, p 1040-1046, July 2003

55. Wu Y, Wang P, Ye X, Zhang Q; Li R, Yan W, Zheng X. A novel microphysiometer based on MLAPS for drugs screening. Source: Biosensors & Bioelectronics, v 16, n 4-5, p 277-286, 2001

56. Wu Y, Wang P, Ye X, Zhang G, He H, Yan W, Zheng X, Han J,Cui D.Drug evaluations using a novel microphysiometer based on cell-based biosensors. Source: Sensors And Actuators, B: Chemical, v 80, n 3, p 215-221, December 1, 2001

招生信息：医学、生物、光学、化学化工、材料以及机械等学科专业硕士、博士