tutor
导师介绍
单建贞
教授|博士生导师
浙江大学医学院附属第一医院肿瘤内四科主任
shanjz@zju.edu.com
浙江大学医学院附属第一医院
个人简介
单建贞,女,1972年5月,医学博士,主任医师,浙江大学医学院附属第一医院肿瘤内四科主任,美国UCLA访问学者。长期从事消化道肿瘤和肺癌的化疗,免疫治疗,靶向治疗,中西医结合等肿瘤综合内科治疗。
社会兼职:现在担任中国医疗保健国际交流促进会胸部肿瘤专委会委员,CSCO免疫治疗专委会委员,CSCO非小细胞肺癌专委会委员,CSCO非小细胞肺癌指南专家团成员, CSCO患者教育专委会委员,浙江省抗癌协会肿瘤靶向专委会常委,浙江省抗癌协会病因专委会委员,浙江省抗癌协会生物治疗专委会委员,浙江省抗癌协会精准诊疗专委会委员,浙江省抗癌协会中西医结合肿瘤专委会常委
工作经历:
2002年8月在浙医二院工作,2004年12月年晋升为主治医师,2011年12月晋升为肿瘤学副主任医师,2017年12月晋升为肿瘤学主任医师。2014年聘为浙江大学附属第二医院肿瘤学教研室副主任。
2018.2-3在UCLA琼斯癌症中心进修学习。
2020.3-至今,浙大一院肿瘤内四科主任。
参与编写的专著
《癌症可防可治》编委. 浙江大学出版社. 2017,(第三版);参编
发表文章
第一作者论文:
(1) Jianzhen Shan#*, Jian Ruan*, Yanbin Tan, Li Yan, Songan Chen, Miaoyan Du, Lingjie Wang.Effcacy of Pyrotinib in a Heavily PretreatedPatient with Lung Adenocarcinoma HarboringHER2 Amplifcation and Exon 20 Insertions:A Case Report. OncoTargets and Therapy, 2020.10(1): 9849-9856
(2)Jianzhen Shan#,Yanyan Xuan,Qi Zhang,Chunpeng Zhu,Zhe Liu,Suzhan
Zhang*,Ursolic acid synergistically enhances the therapeutic effects ofoxaliplatinin colorectal cancer.protein&cell,2016.7.29,7(8):571~585
(3) Jian zhen SHAN#,Yan-yan XUAN,Qi ZHANG,Jian-jin HUANG*,Ursolicacid sensitized colon cancer cells to chemotherapy underhypoxia by inhibitingMDR1 through HIF-1α ,Journal of Zhejiang University-SCIENCE B (Biomedicine &Biotechnology),2016.01.01,17(9):672~682
(4)ShanJian-zhen#,Xuan, Yan-yan,Ruan, Shu-qin,Sun,Mei*,Proliferation-inhibiting and apoptosis-inducing effects of ursolic acidand oleanolic acid on multi-drug resistance cancer cells in vitro.Chin JIntegr Med,2011.8.01,17(8):607~611
(5)Shan, Jian-zhen#,Xuan, Yan-yan,Zheng, Shu,Dong, Qi,Zhang,Su-zhan*,Ursolic acid inhibits proliferation and induces apoptosis of HT-29colon cancer cells by inhibiting the EGFR/MAPK pathway.,J Zhejiang Univ SciB,2009.9.01,10(9):668~674
(6)Jianzhen Shan# Yanbin Tan, Li,Yan Jian Ruan. Efficacy of pyrotinib in a heavily pretreated patient with lung adenocarcinoma harboring HER2 amplification and exon 20 insertions: a case report. Oncotargets and therapy. 2020(Accepted)
二、通讯作者论文
(1) M. Sun#,J.-J. Zhang,H. Zhang,C.-Y. Jin,S. Xu,Y.-L.J.-Z. Shan*,H. Zhang,C.-Y. Jin,S. Xu,Y.-L Wang. Clinical observation of Danhong Injection (herbal TCM product fromRadixSalviae miltiorrhizae and Flos Carthami tinctorii) in the treatmentof traumaticintracranial hematoma,Phytomedicine,2009.01.01,16:683~689
三、其他论文
(1) Hongyan Qi#,Meng Lou,Yuexia Chen,Xiyong Liu,Naiming Chen,Jianzhen Shan,Zhiqiang Ling,Jing Shen,Lijun Zhu,Yun Yen,Shu Zheng,JiminShao*.Non-enzymatic action of RRM1 protein upregulates PTENleading toinhibition of colorectal cancer metastasis,TumorBiology,2015.01.01,36:4833~4842
(2) Hongyan Qi#,Huifang Zhu,Meng Lou,Yanfeng Fan,Hong Liu,JingShen,Zhongjie Li,Xue Lv, Jianzhen Shan,Lijun Zhu,Y. Eugene Chin,Jimin Shao* . Interferon Regulatory Factor 1 Transactivates Expression ofHuman DNAPolymerase in Response to CarcinogenN-Methyl-N-nitro-N-nitrosoguanidine,THEJOURNAL OF BIOLOGICAL CHEMISTRY,2012.2.24,287(16):12622~12633
(3) Yongmao Song#,Modan L,Xiaoxian Ye,Shangyi, Jianzhen Shan,Shangyi Tang,Xuefeng Fang,Kefeng Ding,Ying Yuan*.Acute small bowel obstruction: arare initialpresentation for the metastasis of the large-cellcarcinoma of thelungWorld Journal of Surgical Oncology,2012,10:26
(4) Sun, Mei#*, Zhan, Xiao-ping,Jin, Chen-yu,Shan, Jian-zhen,Xu,Shu,Wang, Yun-lai,Clinical observation on treatment of post-craniocerebraltraumatic mental disorder by integrative medicine.,Chinese Journal ofIntegrative Medicine2008.6.01,14(2):137~141
(5)Wang Y#, Peng C*, Zhang G, Liu Y, Li H, Shan J. Study on invasion andmetastasis related factors in differentiation of SMMC-7721 cells induced by matrine.Zhong Yao Cai. 2003 Aug;26(8):566-569.
(6) 金晨宇, 单建贞, 包洁, 胡蕾, 何若苹 . 益气养阴法治疗老年原发性支气管
肺癌的效果. 中国老年病杂志,2017,11:4280-4282.