tutor

导师介绍

单建贞

教授|博士生导师

浙江大学医学院附属第一医院肿瘤内四科主任

电话

邮箱

shanjz@zju.edu.com

地址

浙江大学医学院附属第一医院

个人简介


单建贞19725医学博士,主任医师浙江大学医学院附属第一医院肿瘤内四科主任美国UCLA访问学者长期从事消化道肿瘤和肺癌的化疗,免疫治疗,靶向治疗,中西医结合等肿瘤综合内科治疗。

社会兼职现在担任中国医疗保健国际交流促进会胸部肿瘤专委会委员,CSCO免疫治疗专委会委员,CSCO非小细胞肺癌专委会委员,CSCO非小细胞肺癌指南专家团成员, CSCO患者教育专委会委员,浙江省抗癌协会肿瘤靶向专委会常委浙江省抗癌协会病因专委会委员浙江省抗癌协会生物治疗专委会委员浙江省抗癌协会精准诊疗专委会委员浙江省抗癌协会中西医结合肿瘤专委会常委


工作经历:

 20028月在浙医二院工作,200412月年晋升为主治医师,201112晋升为肿瘤学副主任医师201712月晋升为肿瘤学主任医师2014年聘为浙江大学附属第二医院肿瘤学教研室副主任。

 2018.2-3UCLA琼斯癌症中心进修学习。

 2020.3-至今,浙大一院肿瘤内四科主任。


参与编写的

  1. 癌症可防可治》编委. 浙江大学出版社. 2017,();参编


发表文章

  1. 第一作者论文:

 (1) Jianzhen Shan#*, Jian Ruan*, Yanbin Tan, Li Yan, Songan Chen, Miaoyan Du, Lingjie Wang.Effcacy of Pyrotinib in a Heavily PretreatedPatient with Lung Adenocarcinoma HarboringHER2 Amplifcation and Exon 20 Insertions:A Case Report. OncoTargets and Therapy, 2020.10(1): 9849-9856

2Jianzhen Shan#Yanyan XuanQi ZhangChunpeng ZhuZhe LiuSuzhan
Zhang
*Ursolic acid synergistically enhances the therapeutic effects ofoxaliplatinin colorectal cancer.protein&cell2016.7.2978):571~585
(
3) Jian zhen SHAN#Yan-yan XUANQi ZHANGJian-jin HUANG*Ursolicacid sensitized colon cancer cells to chemotherapy underhypoxia by inhibitingMDR1 through HIF-1α Journal of Zhejiang University-SCIENCE B (Biomedicine &Biotechnology)2016.01.01179):672~682

(4)ShanJian-zhen#Xuan, Yan-yanRuan, Shu-qinSun,Mei*Proliferation-inhibiting and apoptosis-inducing effects of ursolic acidand oleanolic acid on multi-drug resistance cancer cells in vitro.Chin JIntegr Med2011.8.01178):607~611
(
5)Shan, Jian-zhen#Xuan, Yan-yanZheng, ShuDong, QiZhang,Su-zhan*Ursolic acid inhibits proliferation and induces apoptosis of HT-29colon cancer cells by inhibiting the EGFR/MAPK pathway.J Zhejiang Univ SciB2009.9.01109):668~674

6Jianzhen Shan# Yanbin Tan, Li,Yan Jian Ruan. Efficacy of pyrotinib in a heavily pretreated patient with lung adenocarcinoma harboring HER2 amplification and exon 20 insertions: a case report. Oncotargets and therapy. 2020Accepted

二、通讯作者论文

 (1) M. Sun#J.-J. Zhang,H. ZhangC.-Y. JinS. XuY.-L.J.-Z. Shan*,H. ZhangC.-Y. JinS. XuY.-L Wang. Clinical observation of Danhong Injection (herbal TCM product fromRadixSalviae miltiorrhizae and Flos Carthami tinctorii) in the treatmentof traumaticintracranial hematomaPhytomedicine2009.01.0116683~689

三、其他论文

(1) Hongyan Qi#Meng LouYuexia ChenXiyong LiuNaiming ChenJianzhen ShanZhiqiang LingJing ShenLijun ZhuYun YenShu ZhengJiminShao*.Non-enzymatic action of RRM1 protein upregulates PTENleading toinhibition of colorectal cancer metastasisTumorBiology2015.01.01364833~4842
(2) Hongyan Qi
#Huifang ZhuMeng LouYanfeng FanHong LiuJingShenZhongjie LiXue LvJianzhen ShanLijun ZhuY. Eugene ChinJimin Shao* .  Interferon Regulatory Factor 1 Transactivates Expression ofHuman DNAPolymerase in Response to CarcinogenN-Methyl-N-nitro-N-nitrosoguanidineTHEJOURNAL OF BIOLOGICAL CHEMISTRY2012.2.2428716):12622~12633
(3) Yongmao Song
#Modan LXiaoxian YeShangyi, Jianzhen Shan,Shangyi TangXuefeng FangKefeng DingYing Yuan*.Acute small bowel obstruction: arare initialpresentation for the metastasis of the large-cellcarcinoma of thelungWorld Journal of Surgical Oncology201210:26
(4) Sun, Mei
#*, Zhan, Xiao-pingJin, Chen-yuShan, Jian-zhenXu,ShuWang, Yun-laiClinical observation on treatment of post-craniocerebraltraumatic mental disorder by integrative medicine.Chinese Journal ofIntegrative Medicine2008.6.01142):137~141

(5)Wang Y#Peng C*Zhang GLiu YLi HShan J. Study on invasion andmetastasis related factors in differentiation of SMMC-7721 cells induced by matrine.Zhong Yao Cai. 2003 Aug;26(8):566-569.

(6) 金晨宇,  单建贞,  包洁,  胡蕾,  何若苹 . 益气养阴法治疗老年原发性支气管


肺癌的效果. 中国老年病杂志,2017,11:4280-4282.





研究方向

消化道肿瘤和肺癌的化疗,免疫治疗,靶向治疗等