研究生教育

浙江大学医学院博士毕业，现任浙大一院放疗科主任，主任医师，博士生导师。担任中国研究型医院放射肿瘤学分会常委，中日医学科技交流协会放射肿瘤专委会副主任委员，浙江省数理医学会精准放疗委员会主任委员，浙江省医学会放射肿瘤学分会副主任委员等学术兼职。长期从事放射学及放射肿瘤学的基础及临床研究，以通讯作者发表放疗领域论文50余篇，多篇发表于放疗专业领域SCI顶级期刊及国内一级期刊。

主持国家自然科学基金、浙江省自然科学基金、浙江省科技厅重点研发项目、“十三五”浙江省中医药重点学科建设项目-中西医结合肿瘤放射治疗学及浙江省中医药管理局重点研究项目等多项课题项目，累及科研经费超500万。参与数项出版物编写。

学习工作经历：

1982年－1985年：浙江绍兴文理学院放射学专业学习。

1989年－1992年：浙江医科大学影像医学硕士研究生。

1992年－2000年：浙江大学医学院附属第一医院放射科工作，历任医师、主治医师和副主任医师。

2000年－2005年：浙江大学博士研究生（在职），其中2002－2003年赴日本神户大学医学部研修放射诊断及治疗学，2004年获医学博士学位，2005年晋升为主任医师。

2005年－至今：  浙江大学医学院附属第一医院放疗科主任。

职务：

担任：浙江大学医学院附属第一医院放射治疗科主任

兼任：中日医学科技交流协会放射肿瘤专委会副主任委员

    浙江省数理医学会精准放疗委员会主任委员

            中国研究型医院学会放射肿瘤学专委会常委

            中国医师学会神经肿瘤分会放疗学组委员

            吴阶平医学基金会肿瘤放疗专委会委员

            中国生物医学工程学会精确放疗分会消化系统肿瘤专委会委员

            中国抗癌协会大肠癌专委会放疗学组委员

            浙江省医学会放射肿瘤学分会副主任委员

            浙江省抗癌协会放疗专委会副主任委员

            浙江省抗癌协会鼻咽癌专委会副主任委员

            浙江省核医学会理事

            浙江省大型医用设备配置管理技术评估专委会委员

            浙江省放射卫生技术评审专家库成员

近期发表主要论文：

1. Tang Q,  Wu L,  Xu M,  Yan D,  Shao J,  Yan S, Osalmid, a Novel Identified RRM2 Inhibitor, Enhances Radiosensitivity of Esophageal Cancer. Int J Radiat Oncol Biol Phys 2020 Aug 04;

2. Zhao F, Wang J, Yu H, Cheng X, Li X, Zhu X, Xu X, Lin J, Chen X, Yan S.Neoadjuvant radiotherapy improves overall survival for T3/4N+M0 rectal cancer patients: a population-based study of 20300 patients. Radiat Oncol. 2020 Feb 27;15(1):49. doi: 10.1186/s13014-020-01497-4.

3. Chen D,  Bao C,  Zhao F,  Yu H,  Zhong G,  Xu L,  Yan S, Exploring Specific miRNA-mRNA Axes With Relationship to Taxanes-Resistance in Breast Cancer. Front Oncol 2020;10. 10.3389/fonc.2020.01397.

4. Xu J,  Wang J,  Zhao F,  Hu W,  Yao G,  Lu Z,  Yan S, The benefits evaluation of abdominal deep inspiration breath hold based on knowledge-based radiotherapy treatment planning for left-sided breast cancer. J Appl Clin Med Phys 2020 Oct;2110(10)

5. Zhao F, Yu X, Xu M, Ye S, Zang S, Zhong W, Ren G, Chen X, Yan S.Mucinous Prostate Cancer Shows Similar Prognosis to Typical Prostate Acinar Carcinoma: A Large Population-Based and Propensity Score-Matched Study.Front Oncol. 2020 Jan 9;9:1467. doi: 10.3389/fonc.2019.01467. eCollection 2019.

6. Wu Lingyun., Tang Qiuying., Yin Xin., Yan DanFang., Tang Mengmeng., Xin Jiaojiao., Pan Qiaoling., Ma Chiyuan., Yan Senxiang.(2019). The Therapeutic Potential of Adipose Tissue-Derived Mesenchymal Stem Cells to Enhance Radiotherapy Effects on Hepatocellular Carcinoma. Front Cell Dev Biol, 7(undefined), 267. doi:10.3389/fcell.2019.00267

7. Zhao Feng., Wang Jili., Yu Hao., Cheng Xiaofei., Li Xinke., Zhu Xuan., Xu Xiangming., Lin Jianjiang., Chen Xin., Yan Senxiang.(2020). Neoadjuvant radiotherapy improves overall survival for T3/4N+M0 rectal cancer patients: a population-based study of 20300 patients. Radiat Oncol, 15(1), 49. doi:10.1186/s13014-020-01497-4

8. Liu Kaitai., Jin Ming., Ye Shuang., Yan Senxiang.(2020). CHI3L1 promotes proliferation and improves sensitivity to cetuximab in colon cancer cells by down-regulating p53. J. Clin. Lab. Anal., 34(1), e23026. doi:10.1002/jcla.23026

9. Zhao Feng., Yu Xiaokai., Xu Mengyou., Ye Sunyi., Zang Shoumei., Zhong Weixiang., Ren Guoping., Chen Xin., Yan Senxiang.(2019). Mucinous Prostate Cancer Shows Similar Prognosis to Typical Prostate Acinar Carcinoma: A Large Population-Based and Propensity Score-Matched Study. Front Oncol, 9(undefined), 1467. doi:10.3389/fonc.2019.01467

10. Zhao Feng., Wang Jili., Chen Meiqin., Chen Danni., Ye Sunyi., Li Xinke., Chen Xin., Ren Guoping., Yan Senxiang.(2019). Sites of synchronous distant metastases and prognosis in prostate cancer patients with bone metastases at initial diagnosis: a population-based study of 16,643 patients. Clin Transl Med, 8(1), 30. doi:10.1186/s40169-019-0247-4

11. Wang Jingwen., Guan Yun., Gu Weilie., Yan Senxiang., Zhou Juying., Huang Dan., Tong Tong., Li Chao., Cai Sanjun., Zhang Zhen., Zhu Ji.(2019). Long-course neoadjuvant chemoradiotherapy with versus without a concomitant boost in locally advanced rectal cancer: a randomized, multicenter, phase II trial (FDRT-002). Radiat Oncol, 14(1), 215. doi:10.1186/s13014-019-1420-z

12. Yin X, Yan D, Qiu M, Huang L, Yan SX. Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis. BMC Cancer. 2019 Jan 21;19(1):95. doi: 10.1186/s12885-018-5251-3.

13. Wang Lihong., Xie Yalin., Fang Hui., Zhang Xia., Pan Huiyun., Yan Senxiang.(2019). Long noncoding RNA DANCR in various cancers: a meta-analysis and bioinformatics. Cancer Manag Res, 11(undefined), 6581-6592. doi:10.2147/CMAR.S200922

14. Shen Jiayan., Zang Shoumei., Yu Xiaokai., Zhao Feng., Jiang Peng., Zhong Baishu., Zhou Hua., Yan Senxiang.(2019). Management of biochemical recurrence after radical prostatectomy for prostate cancer: A case report. Medicine (Baltimore), 98(27), e16351. doi:10.1097/MD.0000000000016351

15. Yang xin, Lu zhongjie, Zhao Feng, Bu Luyi, Yan Senxiang, SU-I-GPD-T-82 Comparison Study of the Spatial Deviation of Different Bladder Volumes in Prostate Radiotherapy with Pelvic Lymph Node (PLN). Medical physics, 2018 June 45(6), e256

16. Zhao Feng., Shen Jiayan., Yu Xiaokai., Zhou Hua., Lu Zhongjie., Yan Senxiang.(2018). Bone marrow reconversion mimicking pelvis metastases in a patient with rectal cancer: a pitfall on magnetic resonance images. Quant Imaging Med Surg, 8(6), 621-626. doi:10.21037/qims.2018.07.03

17. Liu Kaitai., Wang Ping., Zhu Xinli., Bei Yanping., Zheng Zhen., Yan Senxiang.(2018). Disparities of age-based cancer-specific survival improvement with various clinicopathologic characteristics for kidney cancer. Cancer Manag Res, 10(undefined), 2259-2268. doi:10.2147/CMAR.S169192

18. Tang Qiuying., Zhao Feng., Yu Xiaokai., Wu Lingyun., Lu Zhongjie., Yan Senxiang.(2018). The role of radioprotective spacers in clinical practice: a review. Quant Imaging Med Surg, 8(5), 514-524. doi:10.21037/qims.2018.06.06

19. Zhao Feng., Shen Jiayan., Lu Zhongjie., Luo Yongbiao., Yao Guorong., Bu Luyi., Ge Jia., Yang Xin., Ning Lihua., Yan Senxiang.(2018). Abdominal DIBH reduces the cardiac dose even further: a prospective analysis. Radiat Oncol, 13(1), 116. doi:10.1186/s13014-018-1062-6

20. Zhao Feng, Yao Guorong, Shen Jiayan, Luo Yongbiao, Bu Luyi, Zhu Qibao, Lu Zhongjie, Yan Senxiang. SU-I-GPD-T-346 Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer patients after mastectomy: A dosimetric comparison study. Medical physics, 2018 June 45(6), e319

21. Zhao Feng., Shen Jiayan., Yuan Zuguo., Yu Xiaokai., Jiang Peng., Zhong Baishu., Xiang Jianjian., Ren Guoping., Xie Liping., Yan Senxiang.(2018). Trends in Treatment for Prostate Cancer in China: Preliminary Patterns of Care Study in a Single Institution. J Cancer, 9(10), 1797-1803. doi:10.7150/jca.25113

22. Yan DF, Zhang WB, Ke SB, Zhao F, Yan SX, Wang QD, Teng LS. The prognostic value of pretreatment tumor apparent diffusion coefficient values in nasopharyngeal carcinoma. BMC Cancer. 2017 Oct 11;17(1):678. doi: 10.1186/s12885-017-3658-x.

23. Wang Fang., Tang Qiuying., Lv Guoxiao., Zhao Feng., Jiang Xue., Zhu Xinli., Li Xinke., Yan Senxiang.(2017). Comparison of computed tomography and magnetic resonance imaging in cervical cancer brachytherapy: A systematic review. Brachytherapy, 16(2), 353-365. doi:10.1016/j.brachy.2016.11.001

24. Zhao F, Yu X, Shen J, Li X, Yao G, Sun X, Wang F, Zhou H, Lu Z, Yan S. Magnetic susceptibility artefact on MRI mimicking lymphadenopathy: description of a nasopharyngeal carcinoma patient. Transl Cancer Res 2017. doi: 10.21037/tcr.2017.09.16

25. Zhao F, Bu L, Zhang W, Yao G, Yu X, Li X, Wang F, Jiang X, Lu Z, Yan S. Herpes simplex encephalitis during radiation therapy in a patient with nasopharyngeal carcinoma. Transl Cancer Res 2017. doi: 10.21037/ tcr.2017.06.04

26. Zhao Feng, Lu Zhongjie, Yao Guorong, Yan Senxiang, SU – I – GPD – T – 511 - Different Breathing Maneuvers for DIBH During Radiotherapy for Left-Sided Breast Cancer, Medical Physics, 44 (6), June 2017, 2946-2947

27. Sun X-L., Cao G-H., Cao Y., Jiang X., Li X-K., Ye X-H., Wang D-H., Yan S-X.(2016). Association of LncRNA HMlincRNA717 with prognosis in pancreatic cancer. Eur Rev Med Pharmacol Sci, 20(11), 2230-4.

28. Fang Jin., Zhou Shui-Hong., Fan Jun., Yan Sen-Xiang.(2015). Roles of glucose transporter-1 and the phosphatidylinositol 3‑kinase/protein kinase B pathway in cancer radioresistance (review). Mol Med Rep, 11(3), 1573-81. doi:10.3892/mmr.2014.2888

29. Yan DanFang., Yan SenXiang., Lu ZhongJie., Xie Cong., Chen Wei., Xu Xing., Li Xinke., Yu Haogang., Zhu Xinli., Zheng LingYan.(2014). Postoperative radiotherapy for glioma: improved delineation of the clinical target volume using the geodesic distance calculation. PLoS ONE, 9(6), e98616. doi:10.1371/journal.pone.0098616

30. Yan Danfang., Yan Senxiang., Wang Qidong., Liao Xinbiao., Lu Zhongjie., Wang Yixiang.(2013). Predictors for replanning in loco-regionally advanced nasopharyngeal carcinoma patients undergoing intensity-modulated radiation therapy: a prospective observational study. BMC Cancer, 13(undefined), 548. doi:10.1186/1471-2407-13-548

31. Zheng Lingyan., Yan Senxiang., Yan Danfang., Yang Jingsong., Wang Yixiang.(2013). Fatal bleeding in a nasopharyngeal carcinoma patient after concurrent chemoradiation plus cetuximab: a case report. Onco Targets Ther, 6(undefined), 703-6. doi:10.2147/OTT.S44214

32. Yan Senxiang., Jiang Xue., Yang Jinsong., Yan Danfang., Wang Yi-Xiang J.(2012). Radiotherapy for nasopharyngeal carcinoma and combined capecitabine and nimotuzumab treatment for lung metastases in a liver transplantation recipient: a case experience of sustained complete response. Cancer Biother. Radiopharm., 27(8), 519-23. doi:10.1089/cbr.2012.1206

参加出版物编写：

严森祥，张鑫。骨转移瘤的诊断。见：现代骨转移瘤诊治学。李林法主编。科学出版社2006（ISBN7-03-016384-2）。第七章：133－168页。

严森祥。食管癌的放射治疗。见：食管病学。厉有名主编。人民卫生出版社2010（ISBN 9787117134460）。第十章（第四节）。

严森祥编译：妇科肿瘤的放射治疗。见：放射肿瘤学原理与实践（第5版）。朱广迎等主译。天津科技翻译出版公司 2012（ISBN 978-7-5433-3028-3）。第66章 宫颈癌：1687－1773页。

招生信息：

专业特长：肿瘤的放射诊断及放射治疗，尤其擅长头颈部及胸腹部实体瘤的放射诊断及精确放疗。扎实的放射诊断基础为精确放疗（包括三维适形及调强放疗等）的实施提供了有力保证，目前已培养硕、博士研究生二十余人。

招生范围：科研型及专业型肿瘤学硕士、博士研究生