研究生教育

  浙江大学生命科学学院，求是特聘教授。本科毕业于武汉大学生物系，2004年于新加坡国立大学获得哲学博士学位，2005-2008年于新加坡分子细胞研究院从事博士后、研究员研究工作。长期以来采用斑马鱼以及细胞系为模式体系研究干细胞增殖与分化、器官发育和再生。发现抑癌基因p53存在着新型异构体Δ113p53，该异构体起着拮抗p53细胞凋亡，并促进DNA双链断裂等功能及其分子机制；世界范围内率先揭示“遗传补偿效应”分子机制，为克服“遗传补偿效应”给基因功能研究带来的障碍提出了解决的方法，为人类一些遗传疾病治疗提供了新思路。荣获2019年浙江大学十大学术进展。

代表性论文：

Ting Zhao, Shengfan Ye, Zimu Tang, Liwei Guo, Zhipeng Ma, Yuxi Zhang, Chun Yang, Jinrong Peng, Jun Chen*. Loss-of-function of p53 isoform Δ113p53 accelerates brain aging in zebrafish. Cell Death & Disease. 2021. 12:151。

Shengfan Ye , Ting Zhao, Wei Zhang ,  Zimu Tang , Ce Gao, Zhipeng Ma, Jing-Wei Xiong, Jinrong Peng, Wei-Qiang Tan, Jun Chen*. p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death & Disease. 2020 Jul 23;11(7):568. doi: 10.1038/s41419-020-02781-7.

Gong L, Zhang Q, Pan X, Chen S, Yang L, Lin B, Yang W, Yu L, Xiao ZX, Feng XH, Wang H, Yuan ZM, Peng JR, Tan WQ*, Chen J* (2019). P53 protects cell from death at the heatstroke threshold temperature. Cell Reports 29：3693-3707.

Ma,Z., Zhu,P., Shi,H., Guo,L., Zhang,Q., Chen,Y., Chen,S., Zhang,Z., Peng,J*., and Chen Jun* (2019). PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature 568, 259-263.

Hongjian Gong, Yuxi Zhang, Kunpeng Jiang, Shengfan Ye, Shuming Chen, Qinghe Zhang, Jinrong Peng, Jun Chen*(2018). p73 coordinates with Δ133p53 to promote DNA double-strand break repair. Cell Death & Differentiation, 25(6), 1063-1079.

Yihong Guan, Delai Huang, Feng Chen, Ce Gao, Ting Tao, Hui Shi, Shuyi Zhao, Zuyuan Liao, Li Jan Lo, Yingchun Wang, Jun Chen*, Jinrong Peng* (2016). Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3. PLoS Biology, 14(9): e1002555. doi:10.1371/journal.pbio.1002555.

Lu Gong, Xiao Pan, Zhi-Min Yuan, Jinrong Peng, and Chen J.* (2016) p53 coordinates with Δ133p53 isoform to promote cell survival under low-level oxidative stress. Journal of Molecular cell Biology 8(1): 88-90.

Hu M, Bai Y, Zhang C, Liu F, Cui Z, Chen J*, Peng J* (2016) Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genet, 12(2): e1005881.doi:10.1371/journal.pgen.1005881.

Gong L., Gong H.J., Pan Xiao, Chang C.Q., Ou Z., Ye Y.F., Yin L., Yang L.N., Tao T., Zhang Z.H., Liu C., Lane P.D., Peng J.R., Chen J*. (2015) p53 isoform Δ113p53/Δ133p53 promotes double-strand break repair to protect cell from death and senescence in response to DNA damage. Cell Research. 25:351-269.

Ting Tao, Hui Shi, Yihong Guan, Delai Huang, Ye Chen, David P Lane, Jun Chen*, Jinrong Peng* (2013) Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Research 23:620-634.

招生信息：招收发育生物学和细胞生物学博士生