研究生教育

2013-今        教授          浙江大学生命科学学院

2018-今        双聘教授    浙江大学医学院附属第一医院

2008-2012    博士后       美国加州理工学院

2002-2008    博士          美国俄亥俄州立大学

1998-2002    学士          复旦大学

主要学术荣誉：

2021    中国生物工程学会“张树政糖科学奖”优秀青年奖

2021    日本水谷糖科学基金会 (Mizutani Foundation for Glycoscience) 学术研究奖

2013    International Glycoconjuate Organization 青年糖科学家

2014   国家自然科学基金委“优秀青年”基金

2013   国家高层次人才项目（青年）

2010   Postdoctoral Fellowship, Tobacco-Related Disease Program, California, USA

代表性论文：

1.  zhu Q, Zhou H, Wu L, Lai Z, Geng D, Yang W, Zhang J, Fan Z, Qin W, Wang Y, Zhou R*, Yi W.* 'O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1' Nat. Chem. Biol. 2022 Accepted.

2.  Wu L, Chen, Y, Geng D, Fan Z, Lin B, Zhu Q, Li J, Qin W, Yi W* 'O-GlcNAcylation regulates epidermal growth factor receptor intracellular trafficking and signaling' Proc. Natl. Acad. Sci. USA 2022, 119(10):e2107453119.

3.  He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W* 'Spatiotemporal activation of protein O-GlcNAcylation in living cells' J. Am. Chem. Soc. 2022 doi: 10.1021/jacs.1c11041 (Front Cover)

4.  Tian Y, Zhu Q, Sun Z, Geng D, Lin B, Su X, He J, Guo M, Xu H, Zhao Y, Qin W, Wang PG, Wen L, Yi W.* 'One-step enzymatic labeling reveals a critical role of O-GlcNAcylation in cell-cycle progression and DNA damage response' Angew. Chem. Int. Ed. 2021. 60, 26128-26135. (Hot Paper)

5.  Zhu Q, Cheng X, Cheng Y, Chen J, Huan X, Gao Y, Duan X, Ji J, Li X, Yi W.* 'O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells' Proc. Natl. Acad. Sci. USA 2020, 117, 7755-7763.

6.  Nie H., Ju H., Fan J., Shi X., Cheng Y., Cang X., Zheng Z., Duan X., Yi W.* 'O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth' Nat Commun. 2020, 11: 36.

7.   Li, X., Zhu, Q., Shi, X., Cheng, Y., Li, X., Xu, H., Duan, X., Hsieh-Wilson, L.C., Chu, J., Pelletier, J., Li, S., Yi, W.* 'O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis' Proc. Natl. Acad. Sci. USA 2019, 116, 7857-7866.

8.   Li, J., Li, Z., Duan, X., Yi, W.* 'An isotope-coded photocleavable probe for quantitative profiling of protein O-GlcNAcylation' ACS Chem. Biol. 2019, 14, 4-10.

9.  Rao, X., Duan, X., Mao, W., Li, X., Li, Z., Li, Q., Zheng, Z., Xu, H., Chen, M., Wang, P.G., Wang, Y., Shen, B., Yi, W.* “O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth” Nat. Commun. 2015, 6:8468.

10.  Li, Q., Li, Z., Duan, X. & Yi, W.* “A Tandem Enzymatic Approach for Detecting and Imaging Tumor-Associated TF Antigen Disaccharide” J. Am. Chem. Soc. 2014, 136, 12536-12539.

11. Yi, W., Clark, P., Mason, D., Keenan, M., Hill, C., Goddard III, W., Peters, E., Driggers, E., and Hsieh-Wilson, L.C., “Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism” Science 2012, 337, 975-980.

招生信息：糖化学生物学，肿瘤生物学，干细胞生物学相关方向博士研究生和博士后