研究生教育

2022~至今  兼聘，浙江大学医学院附属第二医院

2021~至今  百人计划研究员，浙江大学生命科学学院

2019~2021  Research Scientist，新加坡癌症科学研究所

2019~2020  访问学者，City of Hope Comprehensive Cancer Center（导师：Markus Muschen教授）

2016~2018  Research Fellow，新加坡癌症科学研究所（导师：H. Phillip Koeffler教授）

2011~2015  博士，杨璐琳医学院，新加坡国立大学（导师：H. Phillip Koeffler教授）

2007~2011  学士，动物科学学院，浙江大学

本课题组以神经胶质瘤、肉瘤等恶性肿瘤为模型，利用病人来源细胞系、临床组织标本及实验动物等材料开展生物医学与肿瘤遗传学研究。同时，结合分子与细胞生物学、化学生物学和生物信息学等研究手段，解析细胞恶性转变和肿瘤发展过程中的生物学改变和遗传学变异，理解肿瘤细胞在染色质重塑、蛋白质稳态及微环境调控等方面的异常行为，探索肿瘤发生机制和干预策略。

学术论文（一作*及通讯作者#论文）

1. Xu L*#, Chen Y*#, Huang Y*, Sandanaraj E, Yu JS, Lin RYT, Dakle P, Ke XY, Chong YK, Koh L, Mayakoda A, Nacro K, Hill J, Huang ML, Gery S, Lim SW, Huang Z, Xu Y, Chen J, Bai L, Wang S, Wakimoto H, Yeo TT, Ang BT, Muschen M, Tang C, Tan TZ#, Koeffler HP. Topography of transcriptionally active chromatin in glioblastoma. Science Advances. 2021 Apr 30; EABD4676.

2. Ke XY, Chen Y#, Tham VY, Lin RY, Dakle P, Nacro K, Puhaindran ME, Houghton P, Pang A, Lee VK, Ding LW, Gery S, Hill J, Chen L, Xu L#, Koeffler HP. MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. Oncogene. 2021 Feb; 40: 1851-1867.

3. Chen Y#, Xu L#, Lin RYT, Muschen M, Koeffler HP. Core transcriptional regulatory circuitries in cancer. Oncogene. 2020 Oct;39(43):6633-6646.

4. Chen Y*, Xu L*#, Mayakoda A*, Huang ML*, Kanojia D*, Tan TZ, Dakle P, Lin RYT, Ke XY, Said JW, Chen J, Gery S, Ding LW, Jiang YY, Pang A, Puhaindran ME, Goh BC, Koeffler HP. Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma. Nature Communications. 2019 Mar 22;10(1):1353.

5. Xu L*#, Chen Y*, Mayakoda A*, Koh L, Chong YK, Buckley DL, Sandanaraj E, Lim SW, Lin RYT, Ke XY, Huang ML, Chen J, Sun W, Wang LZ, Goh BC, Dinh HQ, Kappei D, Winter GE, Ding LW, Ang BT, Berman BP, Bradner JE, Tang C, Koeffler HP. Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5086-E5095.

6. Huang ML#, Chen Y, Yang MQ, Guo AY, Xu Y, Xu L#, Koeffler HP. dbCoRC, a database of core transcriptional regulatory circuitries modeled by H3K27ac ChIP-seq signals. Nucleic Acids Res. 2018 Jan 4;46(D1):D71-D77.

7. Lim SL*, Xu L*, Han BC, Shyamsunder P, Chng WJ, Koeffler HP. Multiple myeloma: combination therapy of BET Bromodomain proteolysis targeting chimeric molecule with CDK9 inhibitor. PLOS One. 2020; 15(6): e0232068.

8. Xu L*, Chen Y*, Dutra-Clarke M*, Mayakoda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching JH, Kovalik JP, Madan V, Chan SL, Muschen M, Breunig JJ, Lin DC, Koeffler HP. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-86.

9. Lin DC*, Xu L*, Chen Y, Yan HY, Hazawa M, Doan N, Said JW, Ding LW , Liu LZ, Yang H, Yu SZ, Kahn M, Yin D, Koeffler HP. Genomic and functional analysis of the E3 ligase PARK2 in glioma. Cancer Research. 2015 May; 75:1815-1827.

10. Lin DC*, Hao JJ*, Nagata Y*, Xu L*, Shang L, Meng X, Sato Y, Okuno Y, Varela AM, Ding LW, Garg M, Liu LZ, Yang H, Yin D, Shi ZZ, Jiang YY, Gu WY, Gong T, Zhang Y, Xu X, Kalid O, Shacham S, Ogawa S, Wang MR, Koeffler HP. Genomic and molecular characterization of esophageal squamous cell carcinoma. Nature Genetics. 2014 Mar; 46: 467-473.

11. Xu L, Lin DC, Yin D, Koeffler HP. An emerging role of PARK2 in cancer. J Mol Med. 2014 Jan; 92(1): 31-42.

12. Lin DC*, Xu L*, Ding LW, Sharma A, Liu LZ, Yang H, Tan P, Vadgama J, Karlan BY, Lester J, Urban N, Schummer M, Doan N, Said JW, Sun H, Walsh M, Thomas CJ, Patel P, Yin D, Chan D, Koeffler HP. Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15): 6109-6114.

招生信息：本课题组长期招募研究生和博士后研究人员，热忱欢迎有兴趣、有理想的同学们加入团队！