研究生教育

        1971.10月出生，籍贯浙江慈溪，医学博士，主任医师，博士研究生导师。1994年毕业于浙江大学医学院，2005～2006年作为访问学者赴美国爱因斯坦医学院长岛犹太医学中心。2013年及2016年分别赴意大利欧洲癌症中心及美国加州大学戴维斯医学中心进修乳腺肿瘤整形术。2011年入选浙江省151人才工程第三层次培养人员，2014年入选浙江省卫生高层次创新人才培养对象，2011年入选浙江省科技创新团队肿瘤学骨干成员。

        一直从事乳腺肿瘤外科临床、教学和科研工作，擅长于乳腺良恶性疾病的诊断和治疗，在慢性复杂性乳腺炎、乳腺癌I/II期乳房重建、乳腺癌保乳根治的肿瘤整形等手术有极高的造诣。作为负责人获国家自然科学基金及省部级课题资助5项，作为主要参与者获省部级科技成果奖2项；作为第一发明人获国家发明专利2项，发表论文近36余篇，其中SCI收录期刊论文17篇；迄今已培养硕士研究生13名,博士生3名。

    主要社会兼职：中国抗癌协会乳腺癌专业委员会委员，中国抗癌协会家族遗传性肿瘤协助组委员，中国医促会乳腺疾病分会常务委员，浙江省抗癌协会乳腺癌专业委员会常务委员，浙江省医师协会乳腺肿瘤专业委员会副主委，浙江省医学会肿瘤外科分会及肿瘤学分会委员。

近5年发表的主要SCI论文

1.Jiaojiao Zhou; Honglian Wang; Fangmeng Fu; Zhanwen Li; Qingjian Feng; Weizhu Wu; Yun Liu, Chuan Wang; Yiding Chen. Spectrum of PALB2 Germline Mutations and Characteristics of PALB2-Related Breast Cancer: Screening of 16,501 Unselected Patients With Breast Cancer and 5890 Controls by Next-Generation Sequencing. Cancer, 2020. DOI: 10.1002/cncr.32905. (Corresponding author) （SCI 6.102）

2.Jiaojiao Zhou; Xuan Zhu; Shijie Wu; Jingxin Guo; Kun Zhang; ChunjingXu; Huihui Chen; Yuxi Jin; Yuting Sun; Shu Zheng; Yiding Chen. Epithelial-mesenchymal transition status of circulating tumor cells in breast cancer and itsclinical relevance, Cancer Biol Med, 2020, 17. (Corresponding author) （SCI 4.602）

3.Shijie Wu; Jiaojiao Zhou; Kun Zhang; Huihui Chen; Meng Luo; Yuexin Lu;Yuting Sun; Yiding Chen; Molecular Mechanisms of PALB2 Function and Its Role in Breast Cancer Management, Front. Oncol., 2020, 10(301). (Corresponding author) （SCI 4.137）

4.Deng M, Chen HH, Zhu X, Luo M, Zhang K, Xu CJ, Hu KM, Cheng P, Zhou JJ, Zheng S, Chen YD. Prevalence and clinical outcomes of germline mutations in BRCA1/2 and PALB2 genes in 2769 unselected breast cancer patients in China. Int J Cancer. 2019 Sep 15;145(6):1517-1528. (Corresponding author) （SCI 7.202）

5.Chen H, Lu W, Zhang Y, Zhu X, Zhou J, Chen Y. A Bayesian network meta-analysis of the efficacy of targeted therapies and chemotherapy for treatment of triple-negative breast cancer. Cancer Med. 2018 Dec 7. doi: 10.1002/cam4.1892. [Epub ahead of print] (Corresponding author) （SCI 3.202）

6.Zhu X, Chen H, Yang Y, Xu C, Zhou J, Zhou J, Chen Y. Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer. Cancer Manag Res. 2018 Dec 5;10:6649-6668. doi: 10.2147/CMAR.S185769. eCollection 2018. (Corresponding author) （SCI 3.702）

7.Xue Y, Lai L, Lian W, Tu X, Zhou J, Dong P, Su D, Wang X, Cao X, Chen Y, Wang Q. SOX9/FXYD3/Src axis is critical for ER+ breast cancer stem cell function.Mol Cancer Res. 2018 Sep 11. pii: molcanres.0610.2018. doi: 10.1158/1541-7786.MCR-18-0610. [Epub ahead of print] （SCI 4.597）

8.Dong LF, Xu SY, Long JP, Wan F, Chen YD. Role of number of sentinel nodes in predicting non-sentinel node metastasis in breast cancer. J Int Med Res. 2018 Feb;46(2):828-835. (Corresponding author) （SCI 1.323）

9.Kong N, Deng M, Sun XN, Chen YD, Sui XB. Polydopamine-Functionalized CA-(PCL-ran-PLA) Nanoparticles for Target Delivery of Docetaxel and Chemo-photothermal Therapy of Breast Cancer. Front Pharmacol. 2018 Feb 21;9:125. doi: 10.3389/fphar.2018.00125. eCollection 2018. (Corresponding author) （SCI 4.4）

10.Zhang K, Zhou J, Zhu X, Luo M, Xu C, Yu J, Deng M, Zheng S, Chen Y. Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer. Breast Cancer Res Treat. 2017 Dec;166(3):865-873. (Corresponding author) （SCI 3.64）

11.Dong LF, Xu SY, Long JP, Wan F, Chen YD. RNA-Sequence Analysis Reveals Differentially Expressed Genes (DEGs) in Patients Exhibiting Different Risks of Tumor Metastasis. Med Sci Monit. 2017 Jun 11;23:2842-2849. (Corresponding author) （SCI 1.585）

12.Dong LF, Xu SY, Long JP, Wan F, Chen YD. Right metastatic occult breast cancer two years after surgery of left breast cancer: a case report and review of the literature. European Journal of Gynaecological Oncology. 2017,4,635-637 (Corresponding author) （SCI 0.692）

13.Xu W, Hu Y, He X, Li J, Pan T, Liu H, Wu X, He H, Ge W, Yu J, Wei Q, Zheng S, Zhang S, Chen Y. Serum profiling by mass spectrometry combined with bioinformatics for the biomarkers discovery in diffuse large B-cell lymphoma. Tumour Biol. 2015 Mar;36(3):2193-9 (Corresponding author) （SCI 3.64）

14.Huang YT, Zhou J, Shi S, Xu HY, Qu F, Zhang D, Chen YD, Yang J, Huang HF, Sheng JZ. Identification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer. Sci Rep. 2015 Jul 29;5:12484. doi: 10.1038/srep12484.

15.Shao Y, Wang B, Shi D, Miao S, Manivel P, Krishna R, Chen Y, Eric Shi Y. Synuclein gamma protects HER2 and renders resistance to Hsp90 disruption. Mol Oncol. 2014 Dec;8(8):1521-31 (Corresponding author) （SCI 5.935）

16.Liang W, Miao S, Zhang B, He S, Shou C, Manivel P, Krishna R, Chen Y, Shi YE. Synuclein γ protects Akt and mTOR and renders tumor resistance to Hsp90 disruption. Oncogene. 2015 Apr 30;34(18):2398-405. (Corresponding author) （SCI 8.559）