人才队伍

 团队带头人黄建，博士，主任医师，博士生导师。现为浙江大学医学院附属第二医院副院长，浙江大学“求是”特聘医师、省医药卫生高层次创新人才、省有突出贡献中青年专家、151人才一层次2016年省十佳优秀科技工作者、国家卫健委和浙江省G20先进个人等。现任浙江省肿瘤微环境与免疫治疗重点实验室主任、国家肿瘤学重点学科和教育部肿瘤学重点实验室方向负责人、浙江大学消化病学研究所副所长；国家基金委二审专家；中国抗癌协会乳腺癌专委会常务委员；中华医学会外科学会乳腺癌学组委员；中国免疫学会理事；浙江省抗癌协会常务理事；浙江省抗癌协会乳腺癌专委会主任委员；浙江省免疫学会副理事长；浙江省免疫学会临床免疫专委会主任委员；中华医学会临床流行病与循证医学专委会常委及浙江省主委；《实用肿瘤杂志》编委。

 黄建教授从事肿瘤（乳腺、胃肠肿瘤）的临床、教学和科学研究工作近30年，围绕临床问题、患者需求，转化为科学问题。作为临床科学家，凭借对科研的热爱和敏锐的学术洞察力，整合临床团队和基础团队，利用新鲜的肿瘤组织标本和临床信息资料开展转化研究。打造视野开阔、思想先进、技术领先的高精尖团队，并开展多种国内、国际会议和学术交流，扩大影响力。在学科建设、临床新技术开展与推广、论文数量及质量、课题经费、专利申请、国际合作与交流和人才培养等方面取得明显业绩。所获成果受到人民网、浙江日报等数十家多家媒体采访。

 于1996年开始承担国家自然科学基金，先后获得2014年浙江大学十大学术进展、中华医学科技奖三等奖、浙江省医药卫生科技进步奖一等奖，浙江省自然科学奖一等奖。领导并推进全省乳腺癌筛查和规范化治疗（转化。牵头承担临床新药试验项目1-3，adc药物1期临床试验，CTC诊断项目）。近五年来主持包括国家重大新药创制项目、国家自然科学基金（含重点项目、国际合作重大计划、面上项目）、国家科技部973计划前期预研项目、浙江省重大科技专项、浙江省自然基金重点项目和杰青项目、省部共建重大课题等。

 主持建设浙江省肿瘤免疫诊断与治疗新技术研发国际合作基地和浙江省肿瘤微环境与免疫治疗重点实验室。受邀在国际γδT免疫学大会（伦敦，2016）和全国免疫学大会（2015，2016）报告，并任国际γδT免疫学大会（北京，2020）共同主席，在国内外学术界有较高的知名度和影响力；培养研究生59名（博士后和博士25名），其中1位以第一作者在Immunity发表论文，1位研究成果Gut杂志修回，2位获中国免疫学会青年学者奖，培养博士生连续4年毕业当年获国家自然科学基金资助；近年来指导的博士生分获2014和2015年浙大优秀博士论文提名，是全校唯一一位连续2年获浙大优秀博士论文提名的导师。

一、科研项目

1.国家自然科学基金重点项目，81930079，γδT细胞异质性介导微生境失衡促进大肠癌演进的关键机理，2020.1-2024.12，297万，负责人；

2.国家自然科学基金国际（地区）合作与交流项目，81520108024，人新型CD39+γδTreg细胞在促进大肠癌免疫抑制微环境形成中的作用及机制研究，2016.1-2020.12，282万，负责人；

3.浙江省重点研发计划，免疫、基因及细胞治疗新技术研究-人源化CD73 治疗性抗体研发及其抗肿瘤效应研究，2018.1-2020.12，200万，负责人；

4.浙江省省部共建项目，基于新型分子功能成像和3D打印技术在乳腺癌个性化诊疗中的应用研究，2018.1-2020.12，50万，负责人；

5.国家自然科学基金面上项目，81872317，新型衰老中性粒细胞促进乳腺癌肺转移前免疫微环境形成的作用及关键机制研究，2019.1-2022.12，58万，负责人；

6.国家自然科学基金面上项目，31471391，阿司匹林乙酰化修饰ALDH1选择性清除大肠癌干细胞的分子机制研究，2015.01-2018.12，75万元，在研，负责人；

7.国家重大新药创制，2014ZX09102041-009，基于新型免疫佐剂的抗肿瘤多肽疫苗的临床前研究，2014/01-2016/12，540.63万元，在研，负责人；

8.国家自然科学基金面上项目，81272672，新分子LYRM2促进大肠癌干细胞特性的分子机制及其关键作用靶蛋白鉴定研究，2013/01-2016/12, 78万元，负责人；

二、成果与专利

代表性论文：

1)   P. Wu^#, D. Wu^#, C. Ni^#, J. Ye^#, W. Chen, G. Hu, Z. Wang, C. Wang, Z. Zhang, W. Xia, Z. Chen, K. Wang, T. Zhang, J. Xu, Y. Han, T. Zhang, X. Wu, J. Wang, W. Gong, S. Zheng, F. Qiu, J. Yan*, J. Huang*. gammadeltaT17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer, Immunity, 40 (2014) 785-800. IF:21.522 Citation：213

2)   Yang Y, Li L, Xu C, Wang Y, Wang Z, Chen M, Jiang Z, Pan J, Yang C, Li X, Song K, Yan J, Xie W, Wu X, Chen Z, Yuan Y, Zheng S, Yan J, Huang J, Qiu F. Cross-talk between the gut microbiota and monocyte-like macrophages mediates an inflammatory response to promote colitis-associated tumourigenesis. Gut. 2020 Oct 29:gutjnl-2020-320777.

3)   C. Ni, Q. Fang, W. Chen, J. Jiang, Z. Jiang, J. Ye, T. Zhang, L. Yang, F. Meng, W. Xia, M. Zhong, J. Huang*. Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells. Signal Transduct Target Ther. 5 (2020) 41 IF:5.87 Citation：0

4)   Hu G, Cheng P, Pan J, Wang S, Ding Q, Jiang Z, Cheng L, Shao X, Huang L, Huang J. An IL6-Adenosine Positive Feedback Loop between CD73+ γδTregs and CAFs Promotes Tumor Progression in Human Breast Cancer. Cancer Immunol Res. 2020 Oct;8(10):1273-1286.

5)   Wang Z, Yang C, Li L, Jin X, Zhang Z, Zheng H, Pan J, Shi L, Jiang Z, Su K, Li B, Shao X, Qiu F, Yan J, Huang J. Tumor-derived HMGB1 induces CD62Ldim neutrophil polarization and promotes lung metastasis in triple-negative breast cancer. Oncogenesis. 2020 Sep 17;9(9):82.

6)   Pan J, Zhang L, Shao X, Huang J. Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions. Front Cell Dev Biol. 2020 Jul 7;8:606. 

7)   Zhang L, Pan J, Chen W, Jiang J, Huang J. Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment. Am J Cancer Res. 2020 May 1;10(5):1294-1307.

8)   Zhang Z, Wang W, Wang X, Yu X, Zhu Y, Zhan H, Chen Z, Li B, Huang J. Breast-specific gamma imaging or ultrasonography as adjunct imaging diagnostics in women with mammographically dense breasts. Eur Radiol. 2020 Nov;30(11):6062-6071. 

9)   Jiang J, Pan W, Xu Y, Ni C, Xue D, Chen Z, Chen W, Huang J. Tumour-Infiltrating Immune Cell-Based Subtyping and Signature Gene Analysis in Breast Cancer Based on Gene Expression Profiles. J Cancer. 2020 Jan 14;11(6):1568-1583. 

10)Jiang Z, Cheng P, Luo B, Huang J. Construction and Analysis of a Long Non-Coding RNA-Associated Competing Endogenous RNA Network Identified Potential Prognostic Biomarkers in Luminal Breast Cancer. Onco Targets Ther. 2020 May 18;13:4271-4282.

11)Pan J, Jiang Z, Wu D, Yang C, Wang Z, Huang J. Huaier Extractum Promotes Dendritic Cells Maturation and Favors them to Induce Th1 Immune Response: One of the Mechanisms Underlying Its Anti-Tumor Activity. Integr Cancer Ther. 2020 Jan-Dec;19:1534735420946830. 

12)Shen LS, Jin XY, Wang XM, Tou LZ, Huang J. Advances in endocrine and targeted therapy for hormone-receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer. Chin Med J (Engl). 2020 May 5;133(9):1099-1108.

13)Zhao J, Huang J. Breast cancer immunology and immunotherapy: targeting the programmed cell death protein-1/programmed cell death protein ligand-1. Chin Med J (Engl). 2020 Apr 5;133(7):853-862. 

14) 

15)Z. Chen, W. Li, F. Qiu, Q. Huang, Z. Jiang, J. Ye, P. Cheng, C. Low, Y. Guo, X. Yi, W. Chen, Y. Yu, Y. Han, J. Huang*. Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics. 8(2018) 4447-61
IF:8.063 Citation：9

16)G. Hu#, P. Wu#, P. Cheng#, Z. Zhang, Z. Wang, X. Yu, X. Shao, D. Wu, J. Ye, T. Zhang, X. Wang, F. Qiu, J. Yan*, J. Huang*. Tumor-infiltrating CD39+gammadeltaTregs are novel immunosuppressive T cells in human colorectal cancer, Oncoimmunology, 6 (2017) e1277305.IF:5.333 Citation：23

17)D. Wu#, P. Wu#, X. Wu#, J. Ye, Z. Wang, S. Zhao, C. Ni, G. Hu, J. Xu, Y. Han, T. Zhang, F. Qiu, J. Yan*, J. Huang*. Ex vivo expanded human circulating Vdelta1 gammadeltaT cells exhibit favorable therapeutic potential for colon cancer, Oncoimmunology, 4 (2015) e992749.IF:5.333 Citation：26

18)C. Ni, P. Wu, X. Wu, T. Zhang, T. Zhang, Z. Wang, S. Zhang, F. Qiu, J. Huang*. Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression, Cancer letters, 356 (2015) 579-588.IF:6.508 Citation：18

19)J. Jiang, W. Pan, Y. Xu, C. Ni, D. Xue, Z. Chen, W. Chen, J. Huang*. Tumour-Infiltrating Immune Cell-Based Subtyping and Signature Gene Analysis in Breast Cancer Based on Gene Expression Profiles. J Cancer. 11(2020) 1568-83.IF:3.182 Citation：0

20)Q. Huang, Z. Chen, P. Cheng, Z. Jiang, Z. Wang, Y. Huang, C. Yang, J. Pan, F. Qiu, J. Huang*. LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation. Cancer Lett. 455(2019) 36-47.IF:6.508 Citation：3

21)Y. Yang, C. Xu, D. Wu, Z. Wang, P. Wu, L. Li, J. Huang*, F. Qiu*. γδ T Cells: Crosstalk Between Microbiota, Chronic Inflammation, and Colorectal Cancer. Front Immunol. 9(2018) 1483 IF:4.716  Citation：7

22)J. Pan, C. Yang, Z. Jiang, J. Huang*. Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects. Cancer Manag Res. 11(2019) 1541-1549.IF:2.243  Citation：3

23)Z. Zhang^#, Y. Zhu, Z. Wang, T. Zhang, P. Wu, J. Huang^*. Yin-yang effect of tumor infiltrating B cells in breast cancer: From mechanism to immunotherapy, Cancer letters, 393 (2017) 1-7.IF:6.508 Citation：27

24)D. Wu, P. Wu, F. Qiu, Q. Wei^*, J. Huang^*. Human gammadeltaT-cell subsets and their involvement in tumor immunity, Cell Mol Immunol, 14 (2017) 245-253. IF：8.213 Citation：33

25)Q. Huang^#, S. Li, P. Cheng, M. Deng, X. He, Z. Wang, C.H. Yang, X.Y. Zhao, J. Huang^*. High expression of anti-apoptotic protein Bcl-2 is a good prognostic factor in colorectal cancer: Result of a meta-analysis, World J Gastroenterol, 23 (2017) 5018-5033.IF：3.411 Citation：14

26)W. Chen, J. Jiang, W. Xia, J. Huang^*. Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective, J Immunol Res, 2017 (2017) 1073947.IF：3.404Citation：25

27)X.F. Yu^#, H.J. Yang^#, L. Lei, C. Wang, J. Huang^*. CK19 mRNA in blood can predict non-sentinel lymph node metastasis in breast cancer, Oncotarget, 7 (2016) 30504-30510.IF：0 Citation：4

28)X. Yu^#, G. Hu^#, Z. Zhang^#, F. Qiu, X. Shao, X. Wang, H. Zhan, Y. Chen, Y. Deng, J. Huang^*. Retrospective and comparative analysis of (99m)Tc-Sestamibi breast specific gamma imaging versus mammography, ultrasound, and magnetic resonance imaging for the detection of breast cancer in Chinese women, BMC cancer, 16 (2016) 450.IF：2.933 Citation：7

29)J. Shou, Z. Zhang, Y. Lai, Z. Chen, J. Huang^*. Worse outcome in breast cancer with higher tumor-infiltrating FOXP3+ Tregs : a systematic review and meta-analysis, BMC cancer, 16 (2016) 687.IF：2.933 Citation：36

30)J. Shou, Y. Lai, J. Xu, J. Huang^*. Prognostic value of FOXA1 in breast cancer: A systematic review and meta-analysis, Breast, 27 (2016) 35-43.
 IF：3.494 Citation：18

31)D. Qu, Z. Zhang, X. Yu, J. Zhao, F. Qiu, J. Huang^*. Psychotropic drugs for the management of cancer-related fatigue: a systematic review and meta-analysis, Eur J Cancer Care (Engl), 25 (2016) 970-979.
 IF：2.421 Citation：17

32)S. Zhao^#, D. Wu^#, P. Wu, Z. Wang, J. Huang^*. Serum IL-10 Predicts Worse Outcome in Cancer Patients: A Meta-Analysis, PloS one, 10 (2015) e0139598. IF： 2.776 Citation：30

33)S. Zhao, J. Huang^*, J. Ye^*. A fresh look at zebrafish from the perspective of cancer research, J Exp Clin Cancer Res, 34 (2015) 80.IF：5.646 Citation：41

34)Z. Zhang^#, X. Yu^#, Z. Wang, P. Wu, J. Huang^*. Anthracyclines potentiate anti-tumor immunity: A new opportunity for chemoimmunotherapy, Cancer letters, 369 (2015) 331-335.IF：6.508  Citation：24

35)X. Yu^#, Z. Zhang^#, Z. Wang, P. Wu, F. Qiu, J. Huang^*. Prognostic and predictive value of tumor-infiltrating lymphocytes in breast cancer: a systematic review and meta-analysis, Clin Transl Oncol, (2015).IF：6.508  Citation：49  IF：2.441  Citation：49

36)W. Xia, W. Chen, Z. Zhang, D. Wu, P. Wu, Z. Chen, C. Li, J. Huang^*. Prognostic value, clinicopathologic features and diagnostic accuracy of interleukin-8 in colorectal cancer: a meta-analysis, PloS one, 10 (2015) e0123484. IF： 2.776 Citation：14

37)P. Wu^#, D. Wu^#, L. Li, Y. Chai^*, J. Huang^*. PD-L1 and Survival in Solid Tumors: A Meta-Analysis, PloS one, 10 (2015) e0131403.IF： 2.776  Citation：193

38)D. Wu, P. Wu, L. Zhao, L. Huang, Z. Zhang, S. Zhao, J. Huang^*. NF-kappaB Expression and Outcomes in Solid Tumors: A Systematic Review and Meta-Analysis, Medicine (Baltimore), 94 (2015) e1687.IF：1.87 Citation：7

39)Z. Wang, P. Wu, D. Wu, Z. Zhang, G. Hu, S. Zhao, Y. Lai, J. Huang^*. Prognostic and clinicopathological significance of serum interleukin-6 expression in colorectal cancer: a systematic review and meta-analysis, Onco Targets Ther, 8 (2015) 3793-3801.IF：3.046 Citation：7

专利：

黄建.一种检测胃癌预后与分期血清蛋白质的方法.发明专利,.2012:1/5

黄建.一种来源于肝转移灶的大肠癌细胞系CJF及其构建方法.发明专利,.2012:1/4

黄建.一种来源于外周血Vδ1γδT细胞的体外激活扩增方法.发明专利,.2017:1/4

三、奖励荣誉

1)黄建、邱福铭、伍品、倪超、叶俊。大肠癌微环境的关键免疫调控机制及其干预研究，浙江省自然科学奖一等奖，2017。

2)黄建、邱福铭、伍品、叶俊、吴先国、倪超、王科、王一刻、武当、张涛、陈志刚、朱永良。大肠癌微环境的关键免疫调控机制及其干预研究，浙江省医药卫生科技一等奖，2016。

3)浙大“求是” 特聘教授(医师）

4)浙江省科学技术奖自然科学奖，一等奖，2017

5)浙江省科技进步奖，二等奖，1998

6)教育部霍英东第七届高等院校优秀青年教师奖（科研类），二等奖，2000

7)浙江省科技进步奖，三等奖，2005

8)国家科技进步奖，二等奖，2005

9)“浙江省卫生高层次创新人才”称号，2008