研究生教育

        赵永超，博士，浙江大学转化医学研究院研究员，浙江大学医学院附属第一医院卫生部多器官联合移植研究重点实验室研究员、博士生导师。长期致力于肿瘤发生的分子机制研究，在肿瘤细胞信号调控、肿瘤发生和发展的分子机理以及抗肿瘤药物作用机制等方面积累了丰富的理论和研究经验。迄今为止，在国际权威刊物上发表SCI论文46篇，包括Molecular Cell、Cell Reports等一作和通讯作者29篇（影响因子总和225.242），作为课题负责人主持国家重点研发计划“蛋白质机器与生命过程调控”重点专项子课题1项、作为项目负责人主持国家自然科学基金面上项目3项、国家自然科学基金“生物大分子动态修饰与化学干预”重大研究计划培育项目、浙江省自然科学基金杰青项目、浙江大学多学科交叉种子基金和Susan G. Komen for the Cure基金各1项。

教育经历

2002/9 - 2008/1，清华大学，生物学，博士，导师：周玉祥、程京

1998/9 - 2002/7，厦门大学，生物科学，学士

工作经历

2015/1 - 至今，浙江大学，医学院附属第一医院，研究员

2015/1 - 至今，浙江大学，医学院转化医学研究院，研究员

2008/7 - 2014/12，美国密歇根大学，放射肿瘤系，博士后，合作导师：孙毅教授

代表论文（*通讯作者；#共同一作）

1.Cui D#, Xiong X#, Shu J, Dai X, Sun Y, Zhao Y*. FBXW7 Confers Radiation Survival by Targeting p53 for Degradation. Cell Reports. 2020 Jan 14;30(2):497-509.e4. (IF=8.816, JCR 1区)

2.Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y*. The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth. Cell Death and Differentiation. 2020 Mar;27(3):1119-1133. (IF=10.717, JCR 1区)

3.Chen X#, Xiong X#, Cui D#, Yang F, Wei D, Li H, Shu J, Bi Y, Dai X, Gong L, Sun Y, Zhao Y*. DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals. Oncogene. 2020 Feb;39(7):1557-1571. (IF=7.971, JCR 1区)

4.Ma Y#, Cui D#, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ*, Zhao Y*. SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. 2019 13(2):307-321. (IF=6.574, JCR 1区)

5.Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y*. SCFβ-TrCP-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II. Oncogenesis.2020 Feb 3;9(2):8. (IF=6.119, JCR 1区)

6.Cui D#, Dai X#, Gong L, Chen X, Wang L, Xiong X, Zhao Y*. DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity. Cell Death & Disease. 2020 In press. (IF=6.486, JCR 1区)

7.Xiong X, Cui D, Bi Y, Sun Y*, Zhao Y*. Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival. FASEB Journal.2020 Aug 11; 34(10):13419-13429 (IF=5.394, JCR 1区)

8.Xiong X#, Liu X#, Li H, He H, Sun Y*, Zhao Y*. Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis. Cell Death & Disease. 2018, 9(11):1131. (IF=6.486, JCR 1区)

9.Wang J#, Cui D#, Gu S, Chen X, Bi Y, Xiong X, Zhao Y*. Autophagy regulates apoptosis by targeting NOXA for degradation. BBA Molecular Cell Research. 2018, 1865(8):1105-1113. (IF=5.246, JCR 1区)

10.Chen X, Cui D, Bi Y, Shu J, Xiong X, Zhao Y*. AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. Cell Cycle. 2018, 17(16):2069-2079. (IF=3.699, JCR 2区)

11.Zhao Y*, Tan M, Liu X, Xiong X*, Sun Y*. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death & Disease. 2018, 9(2):145. (IF=6.486, JCR 1区)

12.Zhao Y*, Xiong X, Sun Y*. Cullin-RING Ligase 5: Functional characterization and its role in human cancers. Seminars in Cancer Biology.2020 Apr 22:S1044-579X(20)30085-7 (IF=11.290, JCR 1区)

13.Gu S, Cui D, Chen X, Xiong X*, Zhao Y*. PROTACs: An emerging targeting technique for protein degradation in drug discovery. Bioessays. 2018, 40(4):e1700247. (IF=4.826, JCR 1区) (Highlight by Advanced Science News，入选Web of science高引论文)

14.Bi Y, Cui D, Xiong X, Zhao Y*. The characteristics and roles of β-TrCP1/2 in carcinogenesis. FEBS Journal. 2020 Oct 6. doi: 10.1111/febs.15585. Online ahead of print (IF=4.392, JCR 2区)

15.Cheng J, Lin M, Chu M, Gong L, Bi Y, Zhao Y*. Emerging role of FBXO22 in carcinogenesis. Cell Death Discovery.2020 Jul 27;6:66 (IF=4.114, JCR 2区)

16.Gong L, Cui D, Xiong X*, Zhao Y*. Targeting Cullin-RING Ubiquitin Ligases and the Applications in PROTACs. Advances in Experimental Medicine and Biology. 2020;1217:317-347. (IF=2.450, JCR 2区)

17.Cui D, Xiong X, Zhao Y*. Cullin-RING ligases in regulation of autophagy. Cell Division. 2016, 11:8. (IF=4.692, JCR 2区)

18.Zhao Y, Xiong X, Sun Y*. DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy. Molecular Cell. 2011, 44: 304-16. (IF=16.133, JCR 1区) (Research Highlight by Nature Reviews Molecular Cell Biology)

19.Tan M#, Zhao Y#, Kim S, Liu M, Jia L, Saunders T, Zhu Y*, Sun Y*. SAG/RBX2/ROC2 E3 ubiquitin ligase is essential for vascular and neural development by targeting NF1 for degradation. Developmental Cell. 2011, 21: 1062-76. (IF=10.129, JCR 1区)

20.Xiong X#, Zhao Y#, Tang F, Wei D, Wang X, Thomas D, Zheng P, Liu Y, Sun Y*. Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. eLife. 2014, 3:e02236. (Selected by Faculty of 1000 Cell Biology) (IF=8.175, JCR 1区)

21.Zhao Y, Xiong X, Jia L, Sun Y*. Targeting Cullin-RING ligases by MLN4924 induces autophagy via modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis. Cell Death & Disease. 2012, 3: e386. (IF=6.486, JCR 1区)

22.Zhao Y#, Shao W#, Wei H, Qiao J, Lu Y, Sun Y, Mitchelson K, Cheng J, Zhou Y*. Development of a novel oligonucleotide array-based transcription factor assay platform for genome-wide active transcription factor profiling in Saccharomyces cerevisiae.  Journal of Proteome Research. 2008, 7: 1315-25. (IF=5.675, JCR 1区)

23.Yang Q#, Zhao Y#, Xiong Q, Cheng J*. Rapid chip-based capillary electrophoretic mobility shift assay with negative pressure injection for the binding study of transcription factor Abf1 in Saccharomyces cerevisiae. Electrophoresis. 2008, 29: 5003-9. (IF=3.609, JCR 2区)

24.Zhao Y, Morgan M, Sun Y*. Targeting Neddylation pathways to inactivate cullin-RING ligases for anticancer therapy. Antioxidants & Redox Signaling. 2014, 21(17):2383-400. (IF=7.290, JCR 1区)

25.Zhao Y, Sun Y*. The FBW7-KLF2 axis regulates endothelial functions. Cell Research. 2013, 23:741-3. (IF=20.507, JCR 1区)

26.Zhao Y, Sun Y*. Cullin-RING Ligases as attractive anti-cancer targets. Current Pharmaceutical Design. 2013, 19:3215-25. (IF=3.311, JCR 1区)

27.Yang D#, Zhao Y#, Liu J, Sun Y*, Jia L*. Protective autophagy induced by RBX1/ROC1 knockdown or CRL inactivation via modulating the DEPTOR-MTOR axis. Autophagy. 2012, 8: 1856-8. (IF=11.966, JCR 1区)

28.Zhao Y, Sun Y*. CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome? Cell Research. 2012, 22:1224–6. (IF=20.507, JCR 1区)

29.Zhao Y, Sun Y*. Targeting the mTOR-DEPTOR pathway by CRL E3 ubiquitin ligases: therapeutic application. Neoplasia. 2012, 14: 360-7. (IF=5.696, JCR 1区) (Cover story)

30.Du Y#, Song W#, Chen J, Chen H, Xuan Z, Zhao L, Chen J, Jin C, Zhou M, Tuo B, Zhao Y, Zheng S, Song P*. The potassium channel KCa3.1 promotes cell proliferation by activating SKP2 and metastasis through the EMT pathway in hepatocellular carcinoma. International Journal of Cancer. 2019, 145(2):503-516. (IF=6.485, JCR 1区)

31.魏文毅*、孙毅*、曹诚、常智杰、陈策实、陈佺、程金科、冯仁田、高大明、胡荣贵、贾立军、姜天霞、金建平、李汇华、李卫、刘翠华、刘萱、马蕾娜、缪时英、饶枫、商瑜、宋质银、万勇、王恒彬、王平、王占新、吴缅、吴乔、谢旗、谢松波、谢志平、徐平、许执恒、杨波、阳成伟、应美丹、张宏冰、张令强、赵永超、周军、朱军、王琳芳、张宏、王琛、邱小波*. 类泛素蛋白及其中文命名. 科学通报. 2018, 63(25):2564-2569.

32.Chen J, Song W, Du Y, Li Z, Xuan Z, Zhao L, Chen J, Zhao Y, Tuo B, Zheng S*, Song P*. Inhibition of KLHL21 prevents cholangiocarcinoma progression through regulating cell proliferation and motility, arresting cell cycle and reducing Erk activation. Biochemical and Biophysical Research Communications. 2018, 499(3):433-440. (IF=2.985, JCR 3区)

33.Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y*. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nature Communications. 2017, 8:14002. (IF=13.610, JCR 1区)

34.Song P#, Du Y#, Song W, Chen H, Xuan Z, Zhao L, Chen J, Chen J, Guo D, Jin C, Zhao Y, Tuo B, Zheng S*. KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma. Journal of Cancer. 2017, 8(9):1568-1578. (IF=3.565, JCR 2区)

35.Zhou X#, Tan M#, Nyati M, Zhao Y, Wang G*, Sun Y*. Blockage of neddylation modification stimulates tumor sphere formation in vitro and stem cell differentiation and wound healing in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(21):E2935-44. (IF=10.620, JCR 1区)

36.Klionsky D*, et al, Zhao Y, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016, 12(1):1-222. (IF=11.966, JCR 1区)

37.Li H, Sun G, Zhao Y, Thomas D, Greenson J, Zalupski M, Ben-Josef E, Sun Y*. DEPTOR has growth suppression activity against pancreatic cancer cells. Oncotarget. 2014, 5(24):12811-9. (IF=5.168)

38.Zhou W, Xu J, Zhao Y, Sun Y*. SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization. Oncotarget. 2014, 5:6746-55. (IF=5.168)

39.Li H#, Tan M#, Jia L, Wei D, Zhao Y, Chen G, Zhao L, Thomas D, Bear D, Sun Y*. Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis. Journal of Clinical Investigation. 2014, 124: 835-46. (IF=13.393, JCR 1区)

40.Yang D, Zhao Y, Li A, Wang S, Wang G*, Sun Y*. Smac-mimetic compound SM-164 induces radiosensitization in breast cancer cells through activation of caspases and induction of apoptosis. Breast Cancer Research and Treatment, 2012, 133:189-99. (IF=4.431, JCR 1区)

41.Xiong X, Zhao Y, He HB, Sun Y*. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene, 2011, 30: 1798–1811. (IF=7.971, JCR 1区)

42.Tan M, Zhu Y, Kovacev J, Zhao Y, Pan Z, Spitz, D, Sun Y*. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells. Free Radical Biology and Medicine, 2010, 49: 976-83. (IF=6.456, JCR 1区)

43.Qiao J, Shao W, Wei H, Sun Y, Zhao Y, Xing W, Zhang L, Mitchelson K, Cheng J*. Novel high-throughput profiling of human transcription factors and its use for systematic pathway mapping. Journal of Proteome Research, 2008, 7:2769-79. (IF=5.675, JCR 1区)

44.Sun Y, Zhang Y, Zeng L, Wu J, Wei L, Ren A, Shao W, Qiao J, Zhao Y, Zhang L, Mitchelson K, Cheng J*. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. Journal of Proteome Research, 2008, 7:4455-64. (IF=5.675, JCR 1区)

45.Yin H, Zhao Y, Zhang Y, Zhang H, Xu L, Zou Z, Yang W, Cheng J, Zhou Y*. Genome-wide analysis of the expression profile of Saccharomyces cerevisiae in response to treatment with the plant isoflavone, wighteone, as a potential antifungal agent. Biotechnology Letters, 2006, 28:99-105. (IF=1.982, JCR 3区)

46.Yin H, Xu H, Zhao Y, Yang W, Cheng J, Zhou Y*. Cyclooxygenase- independent effects of aspirin on HT-29 human colon cancer cells, revealed by oligonucleotide microarrays. Biotechnology Letters, 2006, 28:1263-70. (IF=1.982, JCR 3区)

47.Shao W, Wei H, Qiao J, Zhao Y, Sun Y, Zhou Y, Cheng J*. Parallel profiling of active transcription factors using an oligonucleotide array-based transcription factor assay (OATFA). Journal of Proteome Research, 2005, 4:1451-6. (IF=5.675, JCR 1区)

招生信息

本实验室长期欢迎优秀的本科生、硕士、博士研究生和博士后加盟，招收专业：生物化学与分子生物学、肿瘤学，请有意者直接与赵永超老师联系