研究生教育

李永泉浙江大学求是特聘教授、二级教授、博导，享受国务院政府特殊津贴，国家重点研发计划合成生物学重点专项项目首席科学家，入选浙江省151人才工程重点层次。现任浙江大学药物生物技术研究所所长、浙江省微生物生化与代谢工程重点实验室主任、浙江省微生物制药技术工程实验室主任，兼任浙江省微生物学会理事长、中国微生物学会理事兼分子微生物学专委会副主任、中国医药生物技术协会合成生物学分会常务理事、中国生物工程学会合成生物学专委会委员。

研究与成果：长期从事微生物合成生物学和合成生物学制药研究，系统解析了放线菌次级代谢调控的分子机制，建立了以基因组重塑、合成途径定向改造、调控网络重构和基于环境应答的发酵工艺精准优化为核心的微生物合成生物学关键技术；通过产学研合作主导完成他克莫司、纳他霉素、达托霉素、非达霉素等大品种微生物药物的研制或高产改造，支撑合作企业获多项新药证书。 主持了国家重点研发计划项目、国家自然科学基金重点项目、国家自然科学基金重点国际合作项目、863合成生物技术重大专项课题、国家新药创制重大专项课题等项目，授权国家发明专利20余项，获省部级科技进步奖一等奖2项、技术发明奖一等奖1项，以通讯作者在Nature Communication、Journal of Biological Chemistry、Molecular Microbiology、Applied and Environmental Microbiology等领域主流杂志发表110余篇SCI论文。

代表性论文：

[1] Yuan-Yang Guo, Zhen-Hua Li, Tian-Yu Xia, Yi-Ling Du, Xu-Ming Mao*&Yong-Quan Li*， Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis，Nature Communication, 2019, 10：4420.  

[2] Xu-Ming Mao, Shuai Luo, Ri-Cheng Zhou, Feng Wang, Pin Yu, Ning Sun, Xiao-Xia Chen, Yi Tang and Yong-Quan Li*，Transcriptional regulation of the daptomycin gene cluster in Streptomyces roseosporus by an autoregulator AtrA，Journal of Biological Chemistry, 2015, 290（12）:7992–8001.

[3] Chen-Fan Sun, Wei-Feng Xu, Qing-Wei Zhao, Shuai Luo, Xin-Ai Chen, Yong-Quan Li* & Xu-Ming Mao*，Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus，Communications Biology，2020，3:192

[4] Xu-Ming Mao, Wei-Hong Feng, Ning Sun, Zhan Zhou and Yong-Quan Li*. Dual Positive Feedback Regulation of Protein Degradation of an ECF (extra-cytoplasmic function) Sigma Factor for Cell Differentiation in Streptomyces coelicolor, Journal of Biological Chemistry, 2013, 288 （43）：31217-31228

[5] Tan-Jun Wang, Yi-Ming Shan, Han Li, Wei-Wang Dou，Xin-Hang Jiang, Xu-Ming Mao，Shui-Ping Liu，Wen-Jun Guan* and Yong-Quan Li*，Multiple transporters are involved in natamycin efflux in Streptomyces chattanoogensis L10, Molecular Microbiology，2017， 103(4), 713–728

[6] Qing-Ting Bu, Pin Yu, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao^* and Yong-Quan Li^*，Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches，Microbial Cell Factories，2019 18:16 

[7] Jie-Jie Shen, Fu Chen, Xiao-Xuan Wang, Xiao-Fang Liu, Xin-Ai Chen, Xu-Ming Mao* and Yong-Quan Li*，Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups， Frontier in Microbiology, 2018, 9: Article 1840.

[8]Peng-Hui Yuan, Ri-Cheng Zhou, Xuepeng Chen, Shuai Luo, Feng Wang, Xu-Ming Mao*,Yong-Quan Li*, DepR1, aTetR-family transcriptional regulator, positively regulates daptomycin production in an industrial producer Streptomyces roseosporusSW0702, Applied and Environmental Microbiology, 2016，82(6):1898-1905

[9] Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang , Yong-Quan Li*,  WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology, 2014,80(22):6879-6887; 

[10] Jiang H, Wang YY, Guo YY, Shen JJ, Zhang XS, Luo HD, Ren NN, Jiang XH, Li YQ*. An Acyltransferase Domain of FK506 Polyketide Synthase Recognizing Both an Acyl Carrier Protein and Coenzyme A As Acyl Donors To Transfer Allylmalonyl and Ethylmalonyl Units. FEBS Journal. 2015, 282: 2527–2539

[11] Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang , Yong-Quan Li*,  WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology, 2014,80(22):6879-6887

[12] Hui Jiang, Yue-Yue Wang, Wei-Ming Fan, Xin-Hang Jiang,Wen-Jun Guan,* and Yong-Quan Li*. Improvement of Natamycin Production by Engineering of Phosphopanteth Transferases in Streptomyces chattanoogensis L10, Applied and Environmental Microbiology, 2013, 79（11）：3346-3354 

[13] Yi-Ling Du, Xue-Ling Shen, Pin Yu, Lin-Quan Bai, and Yong-Quan Li*，Gamma-Butyrolactone Regulatory System of Streptomyces chattanoogensis Links Nutrient Utilization, Metabolism and Developmental Programme，Applied and Environmental Microbiology，2011, 77（23）：8415–8426

招生信息：微生物合成生物学、微生物制药专业硕士、博士