研究生教育

   浙江大学“求是”特聘教授，国家杰出青年科学基金获得者，国家“万人计划”特聘教授，香港理工大学荣誉教授。浙江大学生物医学工程与仪器科学学院院长，浙江大学医学PET中心主任，浙江大学医学院附属第二医院核医学科主任。两项国家重点研发计划“干细胞及转化研究”专项、“干细胞研究与器官修复”专项首席科学家，两项国家自然科学基金重大科研仪器研制项目负责人，国家自然科学基金重点项目负责人。中国认知科学学会分子影像分会副理事长、医学装备知识产权联盟副理事长、中国感光学会生物影像专委会副主任。

从事重大疾病的分子影像精准诊治研究、医学影像仪器研发，创新基于分子识别和分子示踪的分子影像技术、方法和理论，获得重要技术突破和理论创新，“透明病理”理论提出者，主持制定小儿癫痫及阿尔兹海默病 PET分子影像诊断国际共识指南3部。获教育部科技进步一等奖、中国产学研创新成果一等奖、中国感光学会科技进步一等奖、全国发明展览会金奖、日内瓦国际发明展金奖。

代表性论文：

1.       Enhanced Therapeutic Efficacy of Combining Losartan and Chemo-Immunotherapy for Triple Negative Breast Cancer. Front. Immunol. 2022;https://doi.org/10.3389/ fimmu.2022.938439.

2.       International consensus on the use of tau PET imaging agent F-18-flortaucipir in Alzheimer's disease. Eur J Nucl Med Mol Imaging. 2022;49(3):895-904.

3.       Spatial normalization and quantification approaches of PET imaging for neurological disorders. Eur J Nucl Med Mol Imaging. 2022;doi: 10.1007/s00259-022-05809-6.

4.       Precise Examination of Peripheral Vascular Disease for Diabetics with a Novel Multiplexed NIR-II Fluorescence Imaging Technology. Nano Today. 2020;43:101378.

5.       ¹⁸F-FDG PET/CT findings of mesenchymal hamartoma of the liver in an adolescent. Eur J Nucl Med Mol Imaging. 2022;doi: 10.1007/s00259-022-05874-x.

6.       Processing Speed Dysfunction is Associated with Functional Corticostriatal Circuit Alterations in Childhood Epilepsy with Centrotemporal Spikes: A PET and fMRI Study. Eur J Nucl Med Mol Imaging. 2022;doi: 10.1007/s00259-022-05740-w.

7.       Positron emission tomography molecular imaging-based cancer phenotyping. Cancer. 2022;128(14):2704-2716.

8.       Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances. 2022;8(15):eabk2376.

9.       Spatiotemporal dynamics of brain function during the natural course in a dental pulp injury model. Eur J Nucl Med Mol Imaging. 2022;49(8):2716-2722.

10.    Microbiota-microglia connections in age-related cognition decline. Aging Cell. 2022;21(5):e13599.

11.    High-resolution pediatric age-specific ¹⁸F-FDG PET template: A pilot study in epileptogenic focus localization. Eur J Nucl Med Mol Imaging. 2022;49(5):1560-1573.

12.    Radionuclide Imaging of Apoptosis for Clinical Application. Eur J Nucl Med Mol Imaging. 2022;49(4):1345-1359.

13.    PET imaging of Reactive astrocytes in neurological disorders. Eur J Nucl Med Mol Imaging. 2022;49(4):1275-1287.

14.    Positron Emission Tomography Molecular Imaging for Phenotyping and Management of Lymphoma. Phenomics. 2022.

15.    Neural correlates of beneficial effects of young plasma treatment in aged mice: PET-SPM analyses and neuro-behavioural/molecular biological studies. Eur J Nucl Med Mol Imaging. 2022;49(5):1456-1469.

16.    Quantitative proteomics revealed extensive microenvironmental changes after stem cell transplantation in ischemic stroke. Front Med. 2021;doi: 10.1007/s11684-021-0842-9.

17.    A mitochondria-targeted AIEgen labelled with 18F for breast cancer cell imaging and therapy. Chemistry - An Asian Journal. 2021;16(23):3963-3969.

18.    A novel analytic approach for outcome prediction in diffuse large B-cell lymphoma by ¹⁸F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 2022;49(4):1298-1310.

19.    International consensus on the use of ¹⁸F‑FDG PET/CT in pediatric patients affected by epilepsy. Eur J Nucl Med Mol Imaging. 2021;48(12):3827-3834.

20.    Simultaneous adrenal tuberculosis and renal oncocytoma mimicking malignant masses incidentally detected by ¹⁸F-FDG PET/CT in a patient with lymphoma. Eur J Nucl Med Mol Imaging. 2021;49(2):777-778.

21.    Hemichorea induced by non-ketotic hyperglycemia evaluated with ¹⁸F-FDG and ¹¹C-CFT PET/CT. Eur J Nucl Med Mol Imaging. 2021;48(9):3001-3002.

22.    Positron emission tomography in the COVID-19 pandemic era. Eur J Nucl Med Mol Imaging. 2021;48(12):3903-3917.

23.    Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes. European radiology. 2021;31(12):9335-9345.

24.    A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. ACS Nano. 2021;15(3):5263-5275.

25.    A Deep Learning Framework for ¹⁸F-FDG PET Imaging Diagnosis in Pediatric Patients with Temporal Lobe Epilepsy. Eur J Nucl Med Mol Imaging. 2021;48(8):2476-2485.

26.    Structural, Functional, and Molecular Imaging of Autism Spectrum Disorder. Neuroscience Bulletin. 2021;37(7):1051-1071.

27.    PET imaging of neural activity, β-amyloid, and tau in normal brain aging. Eur J Nucl Med Mol Imaging. 2021;48(12):3859-3871.

28.    Transpathology: molecular imaging based pathology. Eur J Nucl Med Mol Imaging. 2021;48(8):2338-2350.

29.    Resveratrol Promotes the Survival and Neuronal Differentiation of Hypoxia Conditioned NPCs in Rats with Cerebral Ischemia. Frontiers of Medicine. 2021;15(3):472-485.

30.    Systematic imaging in medicine: a comprehensive review. Eur J Nucl Med Mol Imaging. 2021;48(6):1736-1758.

31.    ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-kB Pathway. Front. Med. 2020;7:214.

32.    Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials, 2020 Feb;231:119678.

33.    Aggregation-induced Emission Based Fluorogens for Mitochondria-targeted Tumor Imaging and Theranostics. Chem Asian J. 2020;15(23):3942-3960.

34.    CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021;48(3):708-720.

35.    Radiosynthesis and evaluation of 4-(6-[18F]Fluoro-4-(5-isopropoxy- 1H-indazol-3-yl) pyridin-2-yl)-morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2. RSC Medicinal Chemistry. 2020;11(6):676-684.

36.    Radiosynthesis and evaluation of acetamidobenzoxazolone based radioligand [C-11]N '-MPB for visualization of 18 kDa TSPO in brain. New J Chem. 2020;44(19):7912-7922.

37.    Automated microfluidic chip system for radiosynthesis of PET imaging probes, J Zhejiang Univ-Sci B (Biomed & Biotechnol). 2019;20(11):865-867.

38.    PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2019;46(11):2392-2397.

39.    PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder. Front Med. 2019;13(5):602-609.

40.    Hollow Prussian Blue Nanozymes DriveNeuroprotection againstIschemic Stroke via AttenuatingOxidative Stress, CounteractingInflammation, and Suppressing Cell Apoptosis. Nano Lett. 2019;19(5):2812-2823.

41.    PET Imaging Reveals Brain Metabolic Changes in Adolescent Rats Following Chronic Escalating Morphine Administration. Mol Imaging Biol. 2018;20(6):993-1000.

42.    Light-Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer. Advanced Functional Materials. 2018;201801738.

43.     Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. ACS Nano. 2018;12(2):1321-1338.

44.    ¹⁸F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018;45(9):1567-1572.

45.    High-Efficient Clearable Nanoparticles for Multi-Modal Imaging and Images-Guided Cancer Therapy. Advanced Functional Materials. 2018,28:1704634.

46.    Alteration of monoamine receptor activity and glucose metabolism in paediatric patients with anticonvulsant-induced cognitive impairment. J Nucl Med. 2017;58(9):1490-1497.

47.    Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy. J Nucl Med. 2017;58(8):1293-1299.

48.    Chen Q#, Zhang Y#, Hou H#, Du F, Wu S, Chen L, Shen Y, Chao F, Chung JK, Zhang H, Tian M*. Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging. Eur J Nucl Med Mol Imaging. 2017;44(6):1033-1041.

招生信息：

招收影像医学与核医学、生物医学工程等相关专业博士研究生、硕士研究生、留学生等。